{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:50:32Z","timestamp":1753869032658,"version":"3.41.2"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,5,7]],"date-time":"2021-05-07T00:00:00Z","timestamp":1620345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000589","name":"Chief Scientist Office","doi-asserted-by":"publisher","award":["CZB\/4\/721"],"award-info":[{"award-number":["CZB\/4\/721"]}],"id":[{"id":"10.13039\/501100000589","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Endocrino Diabet &amp; Metabol"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>This study examined the effect of experimentally\u2010induced hypoglycaemia on measures of myocardial blood flow and myocardial injury in adults with, and without, type 1 diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a prospective, randomised, open\u2010label, blinded, endpoint cross\u2010over study, 17 young adults with type 1 diabetes with no cardiovascular risk factors, and 10 healthy non\u2010diabetic volunteers, underwent hyperinsulinaemic\u2010euglycaemic (blood glucose 4.5\u20135.5\u00a0mmol\/L) and hypoglycaemic (2.2\u20132.5\u00a0mmol\/L) clamps. Myocardial blood flow was assessed using transthoracic echocardiography Doppler coronary flow reserve (CFR) and myocardial injury using plasma high\u2010sensitivity cardiac troponin I (hs\u2010cTnI) concentration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During hypoglycaemia, coronary flow reserve trended non\u2010significantly lower in those with type 1 diabetes than in the non\u2010diabetic participants (3.54\u00a0\u00b1\u00a00.47 vs. 3.89\u00a0\u00b1\u00a00.89). A generalised linear mixed\u2010model analysis examined diabetes status and euglycaemia or hypoglycaemia as factors affecting CFR. No statistically significant difference in CFR was observed for diabetes status (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.23) or between euglycaemia and hypoglycaemia (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.31). No changes in hs\u2010cTnI occurred during hypoglycaemia or in the recovery period (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.86).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A small change in CFR was not statistically significant in this study, implying hypoglycaemia may require more than coronary vasomotor dysfunction to cause harm. Further larger studies are required to investigate this putative problem.<\/jats:p><\/jats:sec>","DOI":"10.1002\/edm2.258","type":"journal-article","created":{"date-parts":[[2021,5,8]],"date-time":"2021-05-08T23:01:25Z","timestamp":1620514885000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of hypoglycaemia on measures of myocardial blood flow and myocardial injury in adults with and without type 1 diabetes: A prospective, randomised, open\u2010label, blinded endpoint, cross\u2010over study"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9814-5296","authenticated-orcid":false,"given":"Radzi M.","family":"Noh","sequence":"first","affiliation":[{"name":"Department of Diabetes Royal Infirmary of Edinburgh Edinburgh UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex J.","family":"Graveling","sequence":"additional","affiliation":[{"name":"Department of Diabetes Royal Infirmary of Edinburgh Edinburgh UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ninian N.","family":"Lang","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular Science University of Edinburgh Edinburgh UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Audrey C.","family":"White","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular Science University of Edinburgh Edinburgh UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuan Ken","family":"Lee","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular Science University of Edinburgh Edinburgh UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas L.","family":"Mills","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular Science University of Edinburgh Edinburgh UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David E.","family":"Newby","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular Science University of Edinburgh Edinburgh UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chim C.","family":"Lang","sequence":"additional","affiliation":[{"name":"Division of Molecular and Clinical Medicine University of Dundee Dundee UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian M.","family":"Frier","sequence":"additional","affiliation":[{"name":"Department of Diabetes Royal Infirmary of Edinburgh Edinburgh UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,5,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(13)70112-8"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1706292"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0802743"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0808431"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f4533"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-015-0803-3"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.865"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00266031"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00274791"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-s220"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.2337\/db14-1729"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20040226"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22702"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(98)70194-2"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(98)00389-1"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2002.120968"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.47.2.248"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(97)00242-8"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(98)00389-1"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.9.948"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.338"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.031806"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01658-8"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.49.1.65"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.17.7.697"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-0194"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1979.237.3.E214"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g7873"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00391-8"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-017-0839-9"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-1529"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.992297"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc19-2172"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-0013"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2008.10.018"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9136(199708)14:8<648::AID-DIA418>3.0.CO;2-1"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-007-0902-y"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1504720"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1603827"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-0920"}],"container-title":["Endocrinology, Diabetes &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/edm2.258","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/edm2.258","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/edm2.258","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T21:27:54Z","timestamp":1693344474000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/edm2.258"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,7]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1002\/edm2.258"],"URL":"https:\/\/doi.org\/10.1002\/edm2.258","archive":["Portico"],"relation":{},"ISSN":["2398-9238","2398-9238"],"issn-type":[{"type":"print","value":"2398-9238"},{"type":"electronic","value":"2398-9238"}],"subject":[],"published":{"date-parts":[[2021,5,7]]},"assertion":[{"value":"2021-02-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00258"}}