{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T14:53:33Z","timestamp":1793372013227,"version":"4.5.0"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,7,13]],"date-time":"2021-07-13T00:00:00Z","timestamp":1626134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Endocrino Diabet &amp; Metabol"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Diabetic foot complications, a serious consequence of diabetes mellitus, are associated with a tremendous burden on both individual patients and health care systems. Since prevention strategies may reduce the incidence of this complication, identification of risk factors in large longitudinal studies is essential to optimize early detection and personalized screening of patients at increased risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>We conducted a registry\u2010based retrospective cohort study using data from 10,688 patients with type 2 diabetes mellitus aged \u226518\u00a0years. Cox regression models were used to identify risk factors for foot complications while adjusting for potential confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We observed 140 diabetic foot complications in our patient cohort. The multivariate Cox regression model revealed neuropathy, peripheral arterial disease and male gender as being positively associated with foot complications. The same effect was detected for nephropathy in the time &gt;10\u00a0years after T2DM diagnosis. For higher age at diagnosis and use of insulin, however, a negative association was retrieved.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Male gender and several diabetes\u2010related comorbidities were identified as risk factors for subsequent initial foot complications in patients with type 2 diabetes mellitus. These findings suggest that personalized early detection of patients at increased risk might be feasible by using information on demographics, medical history and comorbidities.<\/jats:p><\/jats:sec>","DOI":"10.1002\/edm2.286","type":"journal-article","created":{"date-parts":[[2021,7,13]],"date-time":"2021-07-13T16:41:25Z","timestamp":1626194485000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Risk factors for diabetic foot complications among patients with type 2 diabetes in Austria\u2013A registry\u2010based retrospective cohort study"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7965-946X","authenticated-orcid":false,"given":"Sophia","family":"Rossboth","sequence":"first","affiliation":[{"name":"Department of Public Health Research Unit for Diabetes Epidemiology Health Services Research and Health Technology Assessment Medical Informatics and Technology UMIT\u2010Private University for Health Sciences Hall i.T. Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedikt","family":"Rossboth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Schoenherr","sequence":"additional","affiliation":[{"name":"Department of Public Health Research Unit for Diabetes Epidemiology Health Services Research and Health Technology Assessment Medical Informatics and Technology UMIT\u2010Private University for Health Sciences Hall i.T. Austria"},{"name":"Department of Internal Medicine St. Vinzenz Hospital Zams Zams Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Lechleitner","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hospital Hochzirl Zirl Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willi","family":"Oberaigner","sequence":"additional","affiliation":[{"name":"Department of Public Health Research Unit for Diabetes Epidemiology Health Services Research and Health Technology Assessment Medical Informatics and Technology UMIT\u2010Private University for Health Sciences Hall i.T. Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,13]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00618-8"},{"key":"e_1_2_11_3_1","volume-title":"IDF Diabetes Atlas","author":"International Diabetes Federation","year":"2019"},{"issue":"10027","key":"e_1_2_11_4_1","first-page":"1513","article-title":"Worldwide trends in diabetes since 1980: a pooled analysis of 751 population\u2010based studies with 4 million participants","volume":"387","author":"Smolen J","year":"2016","journal-title":"Lancet Diabetes Endocrinol"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00045.2011"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.2.217"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2019.09.025"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-2285"},{"key":"e_1_2_11_9_1","first-page":"e3268","article-title":"Definitions and criteria for diabetic foot disease","author":"Netten JJ","year":"2019","journal-title":"Diabetes\/Metab Res Rev"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2014.04.011"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2020.108113"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-019-01376-9"},{"issue":"3","key":"e_1_2_11_13_1","first-page":"36","article-title":"Health\u2010related quality of life and self\u2010esteem in patients with diabetic foot ulcers: results of a cross\u2010sectional comparative study","volume":"57","author":"Meneses LC","year":"2011","journal-title":"Ostomy\u2010Wound Management"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2014.05.009"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2012.03698.x"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2738"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0141076816688346"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2319"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/edm2.175"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0124446"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2694"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.23970\/AHRQEPCREGISTRIES4"},{"key":"e_1_2_11_23_1","volume-title":"Diabetesregister Tirol, Jahresbericht 2019","author":"Leo M","year":"2020"},{"key":"e_1_2_11_24_1","volume-title":"Diabetesregister Tirol: Jahresbericht 2016 und Gesamt\u00fcbersicht 2006 bis 2016","author":"Delmarko I","year":"2018"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00508-019-1450-4"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00508-019-1445-1"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00508-019-1487-4"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2014.07.013"},{"key":"e_1_2_11_29_1","first-page":"3","article-title":"Epidemiology: definition and classification of obesity","author":"Visscher TL","year":"2010","journal-title":"Clinical obesity in adults and children"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00508-019-1471-z"},{"key":"e_1_2_11_31_1","volume-title":"Clinical prediction models: A Practical Approach to Development, Validation, and Updating","author":"Steyerberg EW","year":"2010"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67698-2"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2740"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.12196"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-016-0474-y"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2014.07.016"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2014.07.021"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12263"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/1753-0407.12168"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12902-019-0353-8"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwj281"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2648.2002.02427.x"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.21.7.1071"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2011.08.002"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/8029340"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-0878"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.1193"}],"container-title":["Endocrinology, Diabetes &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/edm2.286","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/edm2.286","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/edm2.286","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T07:50:15Z","timestamp":1693209015000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/edm2.286"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,13]]},"references-count":46,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.1002\/edm2.286"],"URL":"https:\/\/doi.org\/10.1002\/edm2.286","archive":["Portico"],"relation":{},"ISSN":["2398-9238","2398-9238"],"issn-type":[{"value":"2398-9238","type":"print"},{"value":"2398-9238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,13]]},"assertion":[{"value":"2021-02-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00286"}}