{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:50:35Z","timestamp":1753869035912,"version":"3.41.2"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,12,3]],"date-time":"2021-12-03T00:00:00Z","timestamp":1638489600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Endocrino Diabet &amp; Metabol"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>To assess if in adults with COVID\u201019, whether those with diabetes and complications (DM+C) present with a more severe clinical profile and if that relates to increased mortality, compared to those with diabetes with no complications (DM\u2010NC) and those without diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Service\u2010level data was used from 996 adults with laboratory confirmed COVID\u201019 who presented to the Queen Elizabeth Hospital Birmingham, UK, from March to June 2020. All individuals were categorized into DM+C, DM\u2010NC, and non\u2010diabetes groups. Physiological and laboratory measurements in the first 5 days after admission were collated and compared among groups. Cox proportional hazards regression models were used to evaluate associations between diabetes status and the risk of mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 996 individuals, 104 (10.4%) were DM+C, 295 (29.6%) DM\u2010NC and 597 (59.9%) non\u2010diabetes. There were 309 (31.0%) in\u2010hospital deaths documented, 40 (4.0% of total cohort) were DM+C, 99 (9.9%) DM\u2010NC and 170 (17.0%) non\u2010diabetes. Individuals with DM+C were more likely to present with high anion gap\/metabolic acidosis, features of renal impairment, and low albumin\/lymphocyte count than those with DM\u2010NC or those without diabetes. There was no significant difference in mortality rates among the groups: compared to individuals without diabetes, the adjusted HRs were 1.39 (95% CI 0.95\u20132.03, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.093) and 1.18 (95% CI 0.90\u20131.54, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.226) in DM+C and DM\u2010C, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Those with COVID\u201019 and DM+C presented with a more severe clinical and biochemical profile, but this did not associate with increased mortality in this study.<\/jats:p><\/jats:sec>","DOI":"10.1002\/edm2.309","type":"journal-article","created":{"date-parts":[[2021,12,3]],"date-time":"2021-12-03T08:54:53Z","timestamp":1638521693000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The clinical profile and associated mortality in people with and without diabetes with Coronavirus disease 2019 on admission to acute hospital services"],"prefix":"10.1002","volume":"5","author":[{"given":"Krishna","family":"Gokhale","sequence":"first","affiliation":[{"name":"Institute of Applied Health Research University of Birmingham Birmingham UK"},{"name":"School of Computer Science University of Birmingham Birmingham UK"},{"name":"Midlands Health Data Research UK Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0415-7908","authenticated-orcid":false,"given":"Samiul A.","family":"Mostafa","sequence":"additional","affiliation":[{"name":"Department of Diabetes Medicine University Hospitals of Birmingham Birmingham UK"},{"name":"Institute of Metabolism and Systems Research University of Birmingham Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1498-2693","authenticated-orcid":false,"given":"Jingya","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Applied Health Research University of Birmingham Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abd A.","family":"Tahrani","sequence":"additional","affiliation":[{"name":"Institute of Metabolism and Systems Research University of Birmingham Birmingham UK"},{"name":"Department of Diabetes and Endocrinology University Hospitals Birmingham NHS Foundation Trust Birmingham UK"},{"name":"Institute of Cancer and Genomic Sciences University of Birmingham Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher Andrew","family":"Sainsbury","sequence":"additional","affiliation":[{"name":"Institute of Applied Health Research University of Birmingham Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantinos A.","family":"Toulis","sequence":"additional","affiliation":[{"name":"Institute of Applied Health Research University of Birmingham Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. 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