{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T10:53:24Z","timestamp":1758279204536,"version":"3.41.2"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T00:00:00Z","timestamp":1645574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008736","name":"Fondo de Fomento al Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["1160836","1190346"],"award-info":[{"award-number":["1160836","1190346"]}],"id":[{"id":"10.13039\/501100008736","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Endocrino Diabet &amp; Metabol"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Preterm neonates are at risk for metabolic syndrome later in life. Whether prematurity constitutes an independent risk factor for the development of cardiovascular disease and metabolic syndrome remains controversial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare anthropometric measures, cardiometabolic risk factors and insulin resistance variables between children who were born very preterm (VPT, &lt;32\u00a0gestational weeks) and at term (Term, &gt;37\u00a0gestational weeks) and adequate for gestational age (AGA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We designed a cross\u2010sectional cohort study, recruiting 120 children (5.0\u20138.5\u00a0years old) from the preterm clinic at Red de Salud UC\u2010Christus and Complejo Asistencial Dr. S\u00f3tero del R\u00edo, and term children from the community. We excluded children born small for gestational age, based on INTERGROWTH21. Anthropometrics data were classified using WHO reference standards. The homeostasis model assessment insulin resistance (HOMA\u2010IR) index, quantitative insulin sensitivity check index (QUICKI), triglyceride\u2010to\u2010HDL\u2010C ratio (TG\/HDL\u2010C) and Pediatric Score Index for Metabolic Syndrome (PsiMS) were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>VPT children born AGA had lower HDL cholesterol levels (<jats:italic>p\u00a0<\/jats:italic>=\u00a0.019) and a higher PsiMS score than those born at term (<jats:italic>p\u00a0<\/jats:italic>=\u00a0.043). We observed a higher percentage of children with HDL cholesterol \u226440\u00a0mg\/dl (13.0% vs. 2.3%, <jats:italic>p\u00a0<\/jats:italic>=\u00a0.026) and BP \u226590th percentile among the VPT children than among the Term children (26.0% vs. 11.6%, <jats:italic>p\u00a0<\/jats:italic>=\u00a0.031).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>At school age, blood pressure was higher, and HDL\u2010C was lower among VPT children born AGA, suggesting a potential metabolic risk; therefore, it is essential to follow this group throughout their lives.<\/jats:p><\/jats:sec>","DOI":"10.1002\/edm2.329","type":"journal-article","created":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T12:59:55Z","timestamp":1645621195000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Insulin resistance parameters in children born very preterm and adequate for gestational age"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6266-4828","authenticated-orcid":false,"given":"Hern\u00e1n","family":"Garc\u00eda","sequence":"first","affiliation":[{"name":"Pediatric Division School of Medicine Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4426-7009","authenticated-orcid":false,"given":"Carolina","family":"Loureiro","sequence":"additional","affiliation":[{"name":"Pediatric Division School of Medicine Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5046-639X","authenticated-orcid":false,"given":"Helena","family":"Poggi","sequence":"additional","affiliation":[{"name":"Pediatric Division School of Medicine Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5234-0718","authenticated-orcid":false,"given":"Ivonne","family":"D'Apremont","sequence":"additional","affiliation":[{"name":"Pediatric Division School of Medicine Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"},{"name":"Complejo Asistencial Dr. S\u00f3tero del R\u00edo  Puente Alto, Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7417-2508","authenticated-orcid":false,"given":"Rosario","family":"Moore","sequence":"additional","affiliation":[{"name":"Pediatric Division School of Medicine Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Tom\u00e1s","family":"Ossa","sequence":"additional","affiliation":[{"name":"School of Medicine Pontificia Universidad Cat\u00f3lica de Chile  Santiago 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