{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:50:34Z","timestamp":1753869034840,"version":"3.41.2"},"reference-count":61,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T00:00:00Z","timestamp":1658707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Endocrino Diabet &amp; Metabol"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Resveratrol and related polyphenols have therapeutic effects ranging from treatment of depression, Alzheimer's and Parkinson's disease, obesity, diabetes, neurodegeneration and ageing. TRH and TRH\u2010like peptides, with the structure pGlu\u2010X\u2010Pro\u2010NH<jats:sub>2<\/jats:sub>, where \u2018X can be any amino acid reside, have reproductive, caloric\u2010restriction\u2010like, anti\u2010ageing, pancreatic\u2010\u03b2 cell\u2010enhancing, cardiovascular and neuroprotective effects. We hypothesize that TRH and TRH\u2010like peptides are mediators of the therapeutic actions of the resveratrol derivative pterostilbene (PT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixteen young adult male Sprague\u2013Dawley rats were divided into four groups. Control group remained on ad libitum chow and water for 10\u2009days. Acute group received ad libitum chow and water for 9\u2009days and then 0.9\u00a0g PT\/250\u2009g rat chow for 24\u2009h. Chronic animals received PT in chow for 10\u2009days. Withdrawal rats received PT chow for 8\u2009days and then normal chow for 2\u2009days. TRH and TRH\u2010like peptide levels were measured in medulla oblongata (MED), frontal cortex (FCX), hypothalamus (HY), amygdala (AY), hippocampus (HC), piriform cortex (PIR), nucleus accumbens (NA), entorhinal cortex (ENT), striatum (STR), cerebellum (CBL), anterior cingulate (ACNG), posterior cingulate (PCNG), prostate (PR), liver (L), testis (T), heart (H), pancreas (PAN), adrenals (AD) and epididymis (EP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant changes in the levels of TRH and TRH\u2010like peptides occurred throughout the brain and peripheral tissues in response to PT treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The high responsiveness of PIR, CBL, HY, STR, PCNG, MED, FCX, NA, ACNG and AY in brain and EP and PR is consistent with TRH and TRH\u2010like peptides participating in the therapeutic effects of PT.<\/jats:p><\/jats:sec>","DOI":"10.1002\/edm2.356","type":"journal-article","created":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T07:34:20Z","timestamp":1658734460000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A resveratrol derivative modulates <scp>TRH<\/scp> and <scp>TRH<\/scp>\u2010like peptide expression throughout the brain and peripheral tissues of male rats"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8556-0992","authenticated-orcid":false,"given":"Albert Eugene","family":"Pekary","sequence":"first","affiliation":[{"name":"Research VA Greater Los Angeles Healthcare System  Los Angeles California USA"},{"name":"Center for Ulcer Research and Education VA Greater Los Angeles Healthcare System  Los Angeles California USA"},{"name":"Department of Medicine University of California  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert","family":"Sattin","sequence":"additional","affiliation":[{"name":"Research VA Greater Los Angeles Healthcare System  Los Angeles California USA"},{"name":"Psychiatry Services VA Greater Los Angeles Healthcare System  Los Angeles California USA"},{"name":"Department of Psychiatry &amp; 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