{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:40:44Z","timestamp":1786977644371,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T00:00:00Z","timestamp":1666224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Endocrino Diabet & Metabol"],"published-print":{"date-parts":[[2022,11]]},"abstract":"Abstract<\/jats:title>\n \n Introduction<\/jats:title>\n Cardiovascular diseases are very common in the general population, and several factors play a role in their development. The purpose of this study was to investigate the relationship between hyperuricaemia and other cardiovascular disease risk factors.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This cross\u2010sectional study was conducted on 1008 people over the 15\u2010year\u2010old general population in Kerman, Iran. The blood samples of all patients were analysed for the uric acid serum level, and they completed a checklist including physical activity, previous history of hypertension and diabetes, smoking and opium.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A number of 1008 cases of people were entered into the study. According to the results of this study, 254 patients had uric acid levels above the 75th percentile (6\u00a0mg\/dl in males, and 5\u00a0mg\/dl in females). No significant difference was observed between gender (\n p<\/jats:italic>\n \u00a0=\u2009.249) and age groups (\n p<\/jats:italic>\n \u00a0=\u2009.125) of people with and without hyperuricaemia. The prevalence of overweight\/obesity (\n p<\/jats:italic>\n \u00a0<\u2009.001), hypertension (\n p<\/jats:italic>\n \u00a0=\u2009.004) and low physical activity (\n p<\/jats:italic>\n \u00a0=\u2009.033) was significantly higher in patients with hyperuricaemia. The duration of hypertension was significantly higher in hyperuricaemic individuals (\n p<\/jats:italic>\n \u00a0=\u2009.022). Overweight\/obesity (OR\u00a0=\u00a02.67; 95% CI\u00a0=\u00a01.87\u20133.82) and hypertension (OR\u00a0=\u00a01.40; 95% CI\u00a0=\u00a01.02\u20131.93) were two significant independent factors that contributed to the increased risk of hyperuricaemia in the subjects.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n The uric acid serum level is higher in people with hypertension and overweight\/obesity. Hyperuricaemia increases the risk of cardiovascular events, which can be prevented by determining the appropriate strategy for the early diagnosis and treatment of this metabolic disorder.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/edm2.387","type":"journal-article","created":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T00:44:31Z","timestamp":1666313071000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Hyperuricaemia and its association with other risk factors for cardiovascular diseases: A population\u2010based study"],"prefix":"10.1002","volume":"5","author":[{"given":"Farzaneh","family":"Yazdi","sequence":"first","affiliation":[{"name":"Physiology Research Center, Institute of Neuropharmacology Kerman University of Medical Sciences Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Reza","family":"Shakibi","sequence":"additional","affiliation":[{"name":"Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Science Kerman University of Medical Sciences Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4609-9726","authenticated-orcid":false,"given":"Amir","family":"Baniasad","sequence":"additional","affiliation":[{"name":"Resident of Internal Medicine, Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Science Kerman University of Medical Sciences Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8974-2358","authenticated-orcid":false,"given":"Mohammad\u00a0Javad","family":"Najafzadeh","sequence":"additional","affiliation":[{"name":"Medical Intern, Student Research Committee Kerman University of Medical Sciences Kerman 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