{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T06:17:33Z","timestamp":1764569853534,"version":"3.41.2"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Endocrino Diabet &amp; Metabol"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Hyperglycaemic hyperosmolar state (HHS) is a known complication of type 2 diabetes mellitus; however, carbonated carbohydrate fluid intake may precipitate a more severe presentation of type 1 diabetes mellitus with hyperosmolar state. The management of these patients is not easy and can lead to severe complications such as cerebral venous thrombosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We present the case of a 21\u2010month\u2010old boy admitted for consciousness disorders revealing a hyperglycaemic hyperosmolar state on a new\u2010onset type 1 diabetes and who developed cerebral venous thrombosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results and Conclusion<\/jats:title><jats:p>Emergency physicians should be aware of HHS in order to start the appropriate treatment as early as possible and to monitor the potential associated acute complications. This case highlights the importance of decreasing very gradually the osmolarity in order to avoid cerebral complications. Cerebral venous thrombosis in HHS paediatric patients is rarely described, and it is important to recognize that not all episodes of acute neurological deterioration in HHS or diabetic ketoacidosis are caused by cerebral oedema.<\/jats:p><\/jats:sec>","DOI":"10.1002\/edm2.389","type":"journal-article","created":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T09:44:03Z","timestamp":1675244643000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Hyperglycaemic hyperosmolar state and cerebral thrombophlebitis in paediatrics: A case report"],"prefix":"10.1002","volume":"6","author":[{"given":"Maud","family":"Injeyan","sequence":"first","affiliation":[{"name":"Department of Pediatrics CHU de Nantes  Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Baron","sequence":"additional","affiliation":[{"name":"Department of Pediatrics CHU de Nantes  Nantes France"},{"name":"Department of Pediatric Endocrinology CHU de Nantes  Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Lauzier","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit CHU de Nantes  Nantes France"},{"name":"Universit\u00e9 de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax  Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benedicte","family":"Gaillard\u2010Le Roux","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit CHU de Nantes  Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1081-7829","authenticated-orcid":false,"given":"Manon","family":"Denis","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit CHU de Nantes  Nantes France"},{"name":"Universit\u00e9 de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax  Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2013.11.001"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000007369"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2005.10.007"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP-2018-0120"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.2007.20.10.1115"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5448.2012.00897.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2009.11.057"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.6065\/apem.2142002.001"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/PEC.0000000000000167"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-543X.2005.00107.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2007.02553.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200301000-00012"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.113.1.e57"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.86.3.204"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2006.01.010"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2018.11.005"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2003.10.061"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/PEC.0b013e31825d23c9"},{"key":"e_1_2_9_20_1","first-page":"8","article-title":"Hyperosmolar hyperglycemic state","volume":"96","author":"Stoner GD","year":"2017","journal-title":"Am Fam Physician"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.12701"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.2007.20.1.5"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2012.02.005"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2010.09.048"}],"container-title":["Endocrinology, Diabetes &amp; 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