{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T03:16:41Z","timestamp":1792293401168,"version":"4.4.0"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,12,3]],"date-time":"2022-12-03T00:00:00Z","timestamp":1670025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Endocrino Diabet &amp; Metabol"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>This study aimed to investigate the sustained safety and efficacy of insulin treatment simplification with IDegLira in patients with type 2 diabetes and an HbA1c\u2009\u2264\u20097.5% (58\u2009mmol\/mol) during a 12\u2010month follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Seventy\u2010two adults with type 2 diabetes and an HbA1c\u2009\u2264\u20097.5% (58\u2009mmol\/mol) treated with multiple daily insulin injections (MDI) participated in the trial (age 63.8\u2009\u00b1\u20099.5\u2009years, HbA1c 6.4\u2009\u00b1\u20090.7%, [46\u2009\u00b1\u20098\u2009mmol\/mol] body weight 92.95\u2009\u00b1\u200918.83\u2009kg, total daily insulin dose: 43.21\u2009\u00b1\u200910.80\u2009units; mean\u2009\u00b1\u2009SD). Previous insulins were stopped, and once daily IDegLira was started. IDegLira was titrated by the patients to achieve a self\u2010measured prebreakfast plasma glucose concentration of \u22655\u2009mmol\/L to \u22646\u2009mmol\/L.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After 12 months, good glycaemic control was maintained, while body weight decreased significantly. Mean HbA1c changed to 6.2\u2009\u00b1\u20090.8% (44\u2009\u00b1\u20099\u2009mmol\/mol) (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.109) and body weight changed by \u22123.89\u2009kg to 89.06\u2009\u00b1\u200918.61\u2009kg (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.0001). The simplified treatment was safe and well\u2010tolerated. Percentage of patients experiencing at least one episode of hypoglycaemia was 49% during the month before simplification and 17% during the last 3\u00a0months of the follow\u2010up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Insulin treatment simplification with IDegLira in selected patients with type 2 diabetes is safe, maintains adequate glycaemic control and is associated with weight loss over 12\u2009months.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/edm2.390","type":"journal-article","created":{"date-parts":[[2022,12,3]],"date-time":"2022-12-03T03:34:11Z","timestamp":1670038451000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["One\u2010year safety and efficacy results of insulin treatment simplification with\n                    <scp>IDegLira<\/scp>\n                    in type 2 diabetes"],"prefix":"10.1002","volume":"6","author":[{"given":"Zolt\u00e1n J.","family":"Taybani","sequence":"first","affiliation":[{"name":"Department of Endocrinology Dr. R\u00e9thy P\u00e1l Member Hospital, B\u00e9k\u00e9s County Central Hospital  B\u00e9k\u00e9scsaba Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bal\u00e1zs","family":"B\u00f3tyik","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Dr. R\u00e9thy P\u00e1l Member Hospital, B\u00e9k\u00e9s County Central Hospital  B\u00e9k\u00e9scsaba Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e1s","family":"Gyimesi","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Dr. R\u00e9thy P\u00e1l Member Hospital, B\u00e9k\u00e9s County Central Hospital  B\u00e9k\u00e9scsaba Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nika","family":"Katk\u00f3","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Internal Medicine, Faculty of Medicine University of Debrecen  Debrecen Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tam\u00e1s","family":"V\u00e1rkonyi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Szeged  Szeged Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,3]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"S125","article-title":"9. 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