{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T11:54:38Z","timestamp":1791633278945,"version":"4.3.4"},"reference-count":64,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,12,4]],"date-time":"2022-12-04T00:00:00Z","timestamp":1670112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Endocrino Diabet &amp; Metabol"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Neutrophil\u2010to\u2010lymphocyte ratio (NLR) is a routinely available biomarker that reflects systemic inflammation. The study evaluated the predictive value of NLR for ischemic stroke and atrial fibrillation (AF) in patients with type 2 diabetes mellitus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a population\u2010based cohort study of patients with type 2 diabetes mellitus and complete blood count tests at baseline between 1 January 1st, 2009, and 31 December, 2009, at government\u2010funded hospitals\/clinics in Hong Kong. Follow\u2010up was until 31 December, 2019, or death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 85,351 patients (age\u00a0=\u00a067.6\u2009\u00b1\u200913.2\u2009years old, male\u00a0=\u00a048.8%, follow\u2010up\u00a0=\u00a03101\u2009\u00b1\u20091441\u2009days) were included. Univariable Cox regression found that increased NLR at quartiles 2, 3 and 4 was significantly associated with higher risks of new\u2010onset ischemic stroke (hazard ratio [HR]: 1.28 [1.20\u20131.37], <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001, HR: 1.41 [1.32\u20131.51], <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001 and HR: 1.38 [1.29\u20131.47], <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) and AF (HR: 1.09 [1.02\u20131.17], <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.015; HR: 1.28 [1.20\u20131.37], <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001; HR: 1.39 [1.31\u20131.49], <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) compared to quartile 1. On multivariable analysis, NLR remained a significant predictor of ischemic stroke risk for quartiles 2 and 3 (quartile 2: HR: 1.14 [1.05, 1.22], <jats:italic>p<\/jats:italic>\u00a0=\u00a0.001; quartile 3: HR: 1.14 [1.06, 1.23], <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) but not quartile 4 (HR: 1.08 [0.994, 1.17], <jats:italic>p<\/jats:italic>\u00a0=\u00a0.070). NLR was not predictive of AF after adjusting for confounders (quartile 2: HR: 0.966 [0.874, 1.07], <jats:italic>p<\/jats:italic>\u00a0=\u00a0.499; quartile 3: HR: 0.978 [0.884, 1.08], <jats:italic>p<\/jats:italic>\u00a0=\u00a0.661; quartile 4: HR: 1.05 [0.935, 1.16], <jats:italic>p<\/jats:italic>\u00a0=\u00a0.462).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>NLR is a significant predictor of new\u2010onset ischaemic stroke after adjusting for significant confounders in Chinese type 2 diabetes patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/edm2.397","type":"journal-article","created":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T01:49:01Z","timestamp":1670204941000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Predictive value of neutrophil\u2010to\u2010lymphocyte ratio for atrial fibrillation and stroke in type 2 diabetes mellitus: The Hong Kong Diabetes 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