{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T12:24:15Z","timestamp":1761740655806,"version":"3.41.2"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Endocrino Diabet &amp; Metabol"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>There are limited data on the real\u2010world management of diabetes in the Indian population. In this 2\u2010year analysis of the LANDMARC study, the management of type 2 diabetes mellitus (T2DM) and related complications were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This multicenter, observational, prospective study included adults aged \u226525 to \u226460\u2009years diagnosed with T2DM (duration \u22652\u2009years at enrollment) and controlled\/uncontrolled on \u22652 anti\u2010diabetic agents. This interim analysis at 2\u2009years reports the status of glycaemic control, diabetic complications, cardiovascular (CV) risks and therapy, pan\u2010India including metropolitan and non\u2010metropolitan cities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 6234 evaluable patients, 5318 patients completed 2\u2009years in the study. Microvascular complications were observed in 17.6% of patients (1096\/6234); macrovascular complications were observed in 3.1% of patients (195\/6234). Higher number of microvascular complications were noted in patients from non\u2010metropolitan than in metropolitan cities (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001). In 2\u2009years, an improvement of 0.6% from baseline (8.1%) in mean glycated haemoglobin (HbA1c) was noted; 20.8% of patients met optimum glycaemic control (HbA1c\u2009&lt;\u20097%). Hypertension (2679\/3438, 77.9%) and dyslipidaemia (1776\/3438, 51.7%) were the predominant CV risk factors in 2\u2009years. The number of patients taking oral anti\u2010diabetic drugs in combination with insulin increased in 2\u2009years (baseline: 1498\/6234 [24.0%] vs. 2\u2009years: 1917\/5763 [33.3%]). While biguanides and sulfonylureas were the most commonly prescribed, there was an evident increase in the use of dipeptidyl peptidase\u2010IV inhibitors (baseline: 3049\/6234, 48.9% vs. 2\u2009years: 3526\/5763, 61.2%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This longitudinal study represents the control of T2DM, its management and development of complications in Indian population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Trial Registration Number<\/jats:title><jats:p>CTRI\/2017\/05\/008452.<\/jats:p><\/jats:sec>","DOI":"10.1002\/edm2.404","type":"journal-article","created":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T12:42:36Z","timestamp":1675255356000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Two\u2010year trends from the <scp>LANDMARC<\/scp> study: A 3\u2010year, pan\u2010India, prospective, longitudinal study on the management and real\u2010world 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