{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:50:40Z","timestamp":1753869040118,"version":"3.41.2"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T00:00:00Z","timestamp":1680739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004386","name":"Universiti Malaya","doi-asserted-by":"publisher","award":["RP025A\u201014HTM"],"award-info":[{"award-number":["RP025A\u201014HTM"]}],"id":[{"id":"10.13039\/501100004386","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Endocrino Diabet &amp; Metabol"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Overweight and obese children are at risk of obstructive sleep apnoea (OSA) and abnormal pulmonary function (PF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>Investigate the relationship between body mass index (BMI), OSA on PF in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials &amp; Method<\/jats:title><jats:p>Seventy\u2010four children were recruited. Mixed obstructive apnoea\u2010hypopnea index (MOAHI), BMI, oxygen saturation (SpO<jats:sub>2<\/jats:sub>), forced expiratory volume one second (FEV<jats:sub>1<\/jats:sub>), forced vital capacity (FVC) and fractionated exhaled nitric oxide (FeNO) were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010four and thirty children had mild OSA and moderate\u2010to\u2010severe OSA respectively. BMI correlated negatively with SpO<jats:sub>2<\/jats:sub> nadir (<jats:italic>r<\/jats:italic>\u00a0=\u2009\u2212.363, <jats:italic>p<\/jats:italic>\u00a0=\u2009.001). FVC, FEV<jats:sub>1<\/jats:sub> and nadir SpO<jats:sub>2<\/jats:sub> values decreased with OSA severity (<jats:italic>p\u2009&lt;<\/jats:italic>\u00a0.001). The odds of a child with OSA having an abnormal spirometry was 3.16 (95% CI: 1.08, 9.22). There was significant association between FeNO and AHI (<jats:italic>r<\/jats:italic>\u00a0=\u00a0.497, &lt;.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Overweight and obese children with OSA have significant abnormalities in pulmonary function independent of BMI. OSA severity and elevated FeNO also correlated with diminishing lung function.<\/jats:p><\/jats:sec>","DOI":"10.1002\/edm2.417","type":"journal-article","created":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T07:44:55Z","timestamp":1680767095000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pulmonary dysfunction in overweight and obese children with obstructive sleep apnoea"],"prefix":"10.1002","volume":"6","author":[{"given":"Aina Salwa","family":"Kasim","sequence":"first","affiliation":[{"name":"Department of Paediatrics University of Malaya  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahram","family":"Golbabapour","sequence":"additional","affiliation":[{"name":"Rheumatology Research Group, Institute of Inflammation and Ageing University of Birmingham, Queen Elizabeth Hospital  Birmingham 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