{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T07:17:35Z","timestamp":1771485455580,"version":"3.50.1"},"reference-count":66,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T00:00:00Z","timestamp":1681084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Endocrino Diabet &amp; Metabol"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Diabetes mellitus (DM) is a metabolic disorder that affects the body's ability to produce or use insulin. This study evaluated the hypoglycaemic activity of biosynthesized copper oxide nanoparticles (CuO\u2010NPs) in alloxan\u2010induced diabetic Wister rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>CuO\u2010NPs were synthesized via the green route and characterized using different analytical tools. Diabetes was induced intraperitoneally using 90\u2009mg\/kg body weight of alloxan monohydrate in albino rats. Thirty (30) rats were randomly divided into 5 groups of 6 rats each and orally treated for 21\u2009days. Groups I and II were treated with 300\u2009mg\/kg bwt <jats:italic>Cereus hildmannianus<\/jats:italic> extract and CuO\u2010NPs, respectively. Groups III and IV received 5\u2009mg\/kg bwt of Glibenclamide and 2\u2009mL of normal saline, respectively, while Group V was left untreated as the diabetic control. Blood glucose (BG) levels and body weight changes were monitored at 3\u2010 and 7\u2010day intervals, respectively, throughout 21\u2010day treatment period. Lipid profiles, enzyme assays and histopathological studies of the liver were also carried out.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Spheroidal tenorite phase of CuO\u2010NPs with a crystallite size of 62.57\u2009nm, surface area (20.64\u2009m<jats:sup>2<\/jats:sup>\/g) and a UV\u2010maximum absorption at 214.27\u2009nm was formed. The diabetic rats treated with 300\u2009mg\/kg bwt CuO\u2010NPs had the highest BG lowering ability (from 482.75\u2009\u00b1\u200927.70 to 124.50\u2009\u00b1\u20092.50\u2009mg\/dL). A significant difference (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) in weight gain and serum enzymes was also observed in the CuO\u2010NPs treated group compared with other groups. The CuO\u2010NPs\u2010treated group had a significant increase (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) in HDL\u2010cholesterol and a decrease in total cholesterol, triglycerides, LDL\u2010cholesterol and VLDL\u2010cholesterol compared with other groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The green synthesized CuO\u2010NPs nanoparticles significantly reduced (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) blood glucose levels in rats and other associated indices and could serve as drug lead in the treatment of diabetes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/edm2.423","type":"journal-article","created":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T05:24:04Z","timestamp":1681190644000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Hypoglycaemic activity of biosynthesized copper oxide nanoparticles in alloxan\u2010induced diabetic Wister rats"],"prefix":"10.1002","volume":"6","author":[{"given":"Maimuna Bello","family":"Umar","sequence":"first","affiliation":[{"name":"Department of Biochemistry Federal University of Technology  Minna Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1839-1559","authenticated-orcid":false,"given":"Augustine Innalegwu","family":"Daniel","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Federal University of Technology  Minna Nigeria"},{"name":"Department of Biotechnology University of the Western Cape  Bellville South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jimoh Oladejo","family":"Tijani","sequence":"additional","affiliation":[{"name":"Department of Chemistry Federal University of Technology  Minna Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca Olufemi","family":"Akinleye","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Federal University of Technology  Minna Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enriquay","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Biotechnology University of the Western Cape  Bellville South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marshall","family":"Keyster","sequence":"additional","affiliation":[{"name":"Department of Biotechnology University of the Western Cape  Bellville South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashwil","family":"Klein","sequence":"additional","affiliation":[{"name":"Department of Biotechnology University of the Western Cape  Bellville South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,4,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prmcm.2022.100106"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.02.007"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.4172\/2157\u20107439.S6\u2010007"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.procbio.2020.01.008"},{"issue":"1","key":"e_1_2_9_6_1","first-page":"30","article-title":"Prevalence of diabetes, epidemiological characteristics and vascular complications","volume":"93","author":"Russo MP","year":"2023","journal-title":"Arch Cardiol Mex"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570161117666190502103733"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0098-8"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2020.e04508"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40097-019-0301-1"},{"issue":"12","key":"e_1_2_9_11_1","first-page":"374","article-title":"Antibacterial potency of silver nanoparticles synthesized using Boerhaavia diffusa leaf extract as reductive and stabilizing agent","volume":"10","author":"Akintelu SA","year":"2019","journal-title":"Int J Pharma Sci Res"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10973-015-5059-1"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.2166\/aqua.2017.104"},{"key":"e_1_2_9_14_1","doi-asserted-by":"crossref","unstructured":"AminuzzamanM KeiLM LiangWH.Green Synthesis of Copper Oxide (CuO) Nanoparticles Using Banana Peel Extract and their Photocatalytic Activities. 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