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As vitamin C is an antioxidant and thyroid function may be affected and may affect vitamin C levels, for the first time, we aimed to provide a detailed review of all human studies evaluating the different roles of vitamin C in the thyroid gland. Thyroid cancers, goitre, Graves' disease and other causes of hyperthyroidism and hypothyroidism were the conditions discussed in this study. Furthermore, vitamin C addition to other medications such as levothyroxine was also reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this study, we reviewed the relevant literature regarding the association between vitamin C and thyroid diseases using original studies from PubMed, Scopus, Embase, and Web of Science.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In this review, we found anti\u2010cancer effects for intravenous (IV) administration of vitamin C in addition to the beneficial effects of using it in combination with radiotherapy and chemotherapy. As autoimmune diseases affect some antioxidant markers, some studies reported a significant difference in blood vitamin C levels in patients with autoimmune thyroid diseases such as Graves' disease. Despite many studies evaluating the effects of IV administration of vitamin C in mentioned diseases, there is a lack of evidence for oral consumption of vitamin C.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>To conclude, there is a lack of evidence, especially clinical trials, for the therapeutic effects of vitamin C on thyroid diseases; however, promising results were reported in some studies in the literature.<\/jats:p><\/jats:sec>","DOI":"10.1002\/edm2.432","type":"journal-article","created":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T09:07:48Z","timestamp":1685351268000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["The interplay between vitamin C and thyroid"],"prefix":"10.1002","volume":"6","author":[{"given":"Bahareh","family":"Farasati\u00a0Far","sequence":"first","affiliation":[{"name":"Department of Chemistry Iran University of Science and Technology Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir Hossein","family":"Behnoush","sequence":"additional","affiliation":[{"name":"School of Medicine Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elina","family":"Ghondaghsaz","sequence":"additional","affiliation":[{"name":"Undergraduate Program in Neuroscience University of British Columbia Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Amin","family":"Habibi","sequence":"additional","affiliation":[{"name":"Gene, Cell &amp; Tissue Research Institute Tehran University of Medical Science Tehran Iran"},{"name":"Clinical Research Development Center Qom University of Medical Sciences Qom Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6138-1914","authenticated-orcid":false,"given":"Amirmohammad","family":"Khalaji","sequence":"additional","affiliation":[{"name":"School of Medicine Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,29]]},"reference":[{"key":"e_1_2_16_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2015.00397"},{"key":"e_1_2_16_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-2863(98)00002-3"},{"key":"e_1_2_16_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00762777"},{"key":"e_1_2_16_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-016-9837-7"},{"key":"e_1_2_16_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2008.12.018"},{"key":"e_1_2_16_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-5408.2002.00005.x"},{"key":"e_1_2_16_8_1","volume-title":"Physiology, Thyroid Hormone. 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