{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T11:53:21Z","timestamp":1792324401116,"version":"4.4.0"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T00:00:00Z","timestamp":1688428800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Endocrino Diabet &amp; Metabol"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Spermatogenesis is significantly influenced by the thyroid gland. Thyroid disorders can be caused by a variety of factors. Traditionally, <jats:italic>Ellettaria cardamomum<\/jats:italic> has been used to treat a variety of ailments. The effects of <jats:italic>E.\u2009cardamomum<\/jats:italic> extract (ECE) on spermatogenesis in hypothyroid mice were investigated in this study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this study 42 male mice, weighing (25\u201335\u2009g) were randomly divided in six groups: control group (taking normal saline, 0.5\u2009mL\/day, by oral gavage [P.O.]), hypothyroid group (taking 0.1% propylthiouracil in drinking water for 2\u2009weeks), hypothyroid groups treated by levothyroxine (15\u2009mg\/kg\/day, P.O.) and hypothyroid groups treated by ECE (100, 200 and 400\u2009mg\/kg\/day, P.O.). After the end of experiments the mice were anaesthetised and blood samples were collected for hormonal analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The sperm count and microscopic studies of testes were done also. Our results showed that the T<jats:sub>3<\/jats:sub>, T<jats:sub>4<\/jats:sub>, testosterone levels and spermatogenesis in hypothyroid animals decreased and thyroid\u2010stimulating hormone, follicle\u2010stimulating hormone and luteinizing hormone increased compared with control group. Treatment by ECE reverse these effects in comparison with hypothyroid group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>According to our findings, the ECE may stimulates thyroid gland function and increases testosterone and spermatogenesis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/edm2.438","type":"journal-article","created":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T04:16:07Z","timestamp":1688530567000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effect of <i>Elettaria cardamomum<\/i> L. on hormonal changes and spermatogenesis in the propylthiouracil\u2010induced hypothyroidism male BALB\/c mice"],"prefix":"10.1002","volume":"6","author":[{"given":"Bahar","family":"Atabaki","sequence":"first","affiliation":[{"name":"Department of Biology, Faculty of Basic Sciences Islamic Azad University  Hamedan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8664-3220","authenticated-orcid":false,"given":"Naser","family":"Mirazi","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Basic Sciences Bu\u2010Ali Sina University  Hamedan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdolkarim","family":"Hosseini","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences and Biotechnology, Faculty of Life Sciences and Biotechnology Shahid Beheshti University  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdolrahman","family":"Sarihi","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, School of Sciences and Advanced Technology in Medicine Hamadan University of Medical Sciences  Hamadan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Izadi","sequence":"additional","affiliation":[{"name":"Department of Horticulture Sciences and Engineering, Nahavand Higher Education Complex Bu\u2010Ali Sina University  Hamedan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Nourian","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, Faculty of Veterinary Science Bu\u2010Ali Sina University  Hamedan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,4]]},"reference":[{"issue":"3","key":"e_1_2_10_2_1","first-page":"508","article-title":"Infertility and sexual dysfunctions: a systematic literature review","volume":"58","author":"Starc A","year":"2019","journal-title":"Acta Clin Croat"},{"issue":"1","key":"e_1_2_10_3_1","first-page":"7","article-title":"The effects of Ginger on spermatogenesis and sperm parameters of rat","volume":"7","author":"Khaki A","year":"2009","journal-title":"Int J Reprod Biomed"},{"key":"e_1_2_10_4_1","first-page":"1613","volume-title":"Goodman and Gilmans the Pharmacological Basis of Therapeutics","author":"Davis S","year":"2006"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03206"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2016.04.009"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874255601103010098"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2013.00174"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2013.01.040"},{"issue":"1","key":"e_1_2_10_10_1","first-page":"1","article-title":"Plantas descritas originalmente de Honduras y sus nomenclaturas equivalentes actuales","volume":"4","author":"Nelson CH","year":"2001","journal-title":"Ceiba Sci Tech J"},{"issue":"6","key":"e_1_2_10_11_1","first-page":"102","article-title":"Therapeutic uses of Elettaria cardomum","volume":"2","author":"Sharma S","year":"2011","journal-title":"Int J Drug Dev Res"},{"issue":"15","key":"e_1_2_10_12_1","first-page":"1","article-title":"Isolation and identification of phenolic compounds from Elettaria cardamomum seeds and study of their medicinal activity against pathogenic bacteria of prostate gland","volume":"8","author":"Al\u2010Maliki ADM","year":"2011","journal-title":"J Missan Res"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1995-7645(13)60090-5"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1142\/9789812837912_0001"},{"issue":"1","key":"e_1_2_10_15_1","first-page":"27","article-title":"The effect of Elettaria cardamomum L. Fruit's hydroethanolic extract on thyroids hormones serum level in hypothyroid male mice","volume":"21","author":"Taheri S","year":"2016","journal-title":"Armaghane Danesh"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00580-011-1188-5"},{"issue":"4","key":"e_1_2_10_17_1","first-page":"429","article-title":"Effect of wild pistachio oil on serum leptin concentration and thyroid hormones in the male rat","volume":"9","author":"Saeb M","year":"2008","journal-title":"Iran J Endocrinol Metab"},{"issue":"57","key":"e_1_2_10_18_1","first-page":"143","article-title":"Comparative study of the sensitivity and specificity of IgM and IgG assay techniques in the diagnosis of toxoplasmosis","volume":"14","author":"Qaravi M","year":"2008","journal-title":"Razi J Med Sci"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-129-6-3417"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sxmr.2016.05.002"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-016-0952-3"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2008.0257"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-45105"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.FPJ04029X"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4274(98)00332-4"},{"issue":"1","key":"e_1_2_10_26_1","first-page":"94","article-title":"Evaluation of crude drugs by a combination of enfleurage and chromatography\u20104\u2010on flavor components in seeds of Amomum cardamomum and Elettaria cardamomum","volume":"42","author":"Okugawa H","year":"1988","journal-title":"Pharmacogn J"},{"issue":"2","key":"e_1_2_10_27_1","first-page":"21","article-title":"Protective effects of Elettaria cardamomum L. hydroalcoholic extract on serum levels of Gonadotropins and Testosterone in adult male wistar rats induced with Lead acetate","volume":"4","author":"Rezaei E","year":"2016","journal-title":"Jorjani Biomed J"},{"issue":"4","key":"e_1_2_10_28_1","first-page":"239","article-title":"Effects of crude onion extract on murine testis","volume":"10","author":"Nikravesh M\u2010R","year":"2010","journal-title":"J Reprod Infertil"}],"container-title":["Endocrinology, Diabetes &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/edm2.438","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T19:28:44Z","timestamp":1696534124000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/edm2.438"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,4]]},"references-count":27,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1002\/edm2.438"],"URL":"https:\/\/doi.org\/10.1002\/edm2.438","archive":["Portico"],"relation":{},"ISSN":["2398-9238","2398-9238"],"issn-type":[{"value":"2398-9238","type":"print"},{"value":"2398-9238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,4]]},"assertion":[{"value":"2023-03-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e438"}}