{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:18:15Z","timestamp":1777393095076,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T00:00:00Z","timestamp":1689724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004320","name":"Shiraz University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004320","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Endocrino Diabet &amp; Metabol"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Macro\u2010algae products have been shown to ameliorate the metabolic disorders state. Thus, highlighting their function as supplementary therapeutic agents can be a novel strategy for clinical therapies. This systematic review and meta\u2010analysis of clinical trials aimed to summarize the effect of macro\u2010algae consumption on serum lipid profile, glycaemic control and anthropometric factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this systematic review and meta\u2010analysis, a comprehensive search was performed for relevant studies published up to May 2023. The Cochran's <jats:italic>Q<\/jats:italic> test and <jats:italic>I<\/jats:italic>\u2010square (<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>) tests were used to evaluate heterogeneity across the included studies. The meta\u2010analysis was conducted using random\u2010effects model (DerSimonian and Laird), and weighted mean difference (WMD) was considered as the pooled effect size.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of 8602 papers in the initial screening, eight clinical trials with a total of 438 participants were included into this meta\u2010analysis. The results indicated that macro\u2010algae supplementation significantly decreased serum levels of total cholesterol (TC) (WMD\u2009=\u2009\u22126.7\u2009mg\/dL; 95% CI: \u221212.59, \u22120.80; item\u2009=\u20090.026) and low\u2010density lipoprotein cholesterol (LDL\u2010c) (WMD\u2009=\u2009\u22128.25\u2009mg\/dL; 95% CI: \u221215.38, \u22121.12; <jats:italic>p<\/jats:italic>\u2010value\u2009=\u2009.023). There was an increase in level of high\u2010density lipoprotein cholesterol (HDL\u2010c) (WMD\u2009=\u20090.48\u2009mg\/dL; 95% CI: \u22122.05, 3.01; <jats:italic>p<\/jats:italic>\u2010value\u2009=\u2009.71) which was not statistically significant. Macro\u2010algae supplementation reduced body mass index (BMI) (WMD\u2009=\u2009\u22120.28\u2009kg\/m<jats:sup>2<\/jats:sup>; 95% CI: \u22120.96, 0.41; <jats:italic>p<\/jats:italic>\u2010value\u2009=\u2009.426), weight (WMD\u2009=\u2009\u22120.39\u2009kg; 95% CI: \u22123.6, 2.83; <jats:italic>p<\/jats:italic>\u2010value\u2009=\u2009.81), waist circumference (WC) (WMD\u2009=\u2009\u22120.52\u2009cm; 95% CI: \u22122.71, 1.66; <jats:italic>p<\/jats:italic>\u2010value\u2009=\u2009.64), fasting blood sugar (FBS) (WMD\u2009=\u2009\u22121.95\u2009mg\/dL; 95% CI: \u22125.19, 1.28; <jats:italic>p<\/jats:italic>\u2010value\u2009=\u2009.24) and HbA1c (WMD\u2009=\u2009\u22120.02%; 95% CI: \u22120.14, 0.09; <jats:italic>p<\/jats:italic>\u2010value\u2009=\u2009.66) in intervention group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This meta\u2010analysis indicated that macro\u2010algae supplementation significantly decreased TC and LDL\u2010c level. It can also increase HDL\u2010c level and reduce anthropometric indices and glycaemic control factors.<\/jats:p><\/jats:sec>","DOI":"10.1002\/edm2.439","type":"journal-article","created":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T05:10:27Z","timestamp":1689829827000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The effects of macro\u2010algae supplementation on serum lipid, glycaemic control and anthropometric indices: A systematic review and meta\u2010analysis of clinical trials"],"prefix":"10.1002","volume":"6","author":[{"given":"Shahla","family":"Rezaei","sequence":"first","affiliation":[{"name":"Student Research Committee Shiraz University of Medical Sciences  Shiraz Iran"},{"name":"Nutrition Research Center, School of Nutrition and Food Sciences Shiraz University of Medical Sciences  Shiraz 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