{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T11:32:01Z","timestamp":1768822321074,"version":"3.49.0"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T00:00:00Z","timestamp":1696896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Endocrino Diabet &amp; Metabol"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Our study aims to determine the prevalence and factors associated with carotid atherosclerosis in Malagasy Type 2 diabetes mellitus (T2DM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a cross\u2010sectional retrospective study, carried out over a period of 30\u2009months. The diagnosis of carotid atherosclerosis is established by the presence of a carotid plaque increased carotid intima\u2010media thickness\u2009\u22651.1\u2009mm on Doppler ultrasound.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 132 T2DM. The prevalence of carotid atherosclerosis was 63.6% (38.6% carotid plaque and 25% intima\u2010media thickening). After univariate analysis, the factors associated with carotid atherosclerosis were age \u226570\u2009years (3.28 [1.18\u201310, 62]), previous intake of oral antidiabetics (0.33 [0.14\u20130.73]), insulin (0.28 [0.11\u20130.66]) and angiotensin receptor blocker (0.45 [0.20\u20130.98]), and current smoking (5.93 [1.64\u201332.6]). After adjustment for age and gender, previous intake of oral antidiabetics (0.29 [0.13\u20130.64]), insulin (0.27 [0.12\u20130.61]) and angiotensin receptor blocker (0.40 [0.19\u20130.86]), and current smoking (5.98 [1.61\u201322.1]) were associated with carotid atherosclerosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Smoking cessation, education on therapeutic compliance and comprehensive management of all cardiovascular risk factors and T2DM are therefore essential in order to reduce the occurrence of carotid atherosclerosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/edm2.457","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T04:43:37Z","timestamp":1697085817000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prevalence and factors associated with carotid atherosclerosis in a Malagasy population with Type 2 diabetes mellitus: A cross\u2010sectional retrospective study"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0310-7204","authenticated-orcid":false,"given":"Sitraka Angelo","family":"Raharinavalona","sequence":"first","affiliation":[{"name":"Cardiovascular Diseases and Internal Medicine departments Soavinandriana Hospital Center  Antananarivo Madagascar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rija Mikha\u00ebl","family":"Miandrisoa","sequence":"additional","affiliation":[{"name":"Cardiovascular Diseases and Internal Medicine departments Soavinandriana Hospital Center  Antananarivo Madagascar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rija Eric","family":"Raherison","sequence":"additional","affiliation":[{"name":"Endocrinology Department Joseph Raseta Befelatanana University Hospital Center  Antananarivo Madagascar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry","family":"Razanamparany","sequence":"additional","affiliation":[{"name":"Endocrinology Department Joseph Raseta Befelatanana University Hospital Center  Antananarivo Madagascar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radonirina Lazasoa","family":"Andrianasolo","sequence":"additional","affiliation":[{"name":"Endocrinology Department Joseph Raseta Befelatanana University Hospital Center  Antananarivo Madagascar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrianirina Dave Patrick","family":"Rakotomalala","sequence":"additional","affiliation":[{"name":"Endocrinology Department Joseph Raseta Befelatanana University Hospital Center  Antananarivo Madagascar"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,10,10]]},"reference":[{"issue":"143","key":"e_1_2_10_2_1","first-page":"1","article-title":"Classification of atherosclerotic lesions; 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