{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:49:40Z","timestamp":1753868980250,"version":"3.41.2"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T00:00:00Z","timestamp":1700524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000664","name":"Health Technology Assessment Programme","doi-asserted-by":"publisher","award":["15\/171\/01"],"award-info":[{"award-number":["15\/171\/01"]}],"id":[{"id":"10.13039\/501100000664","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Endocrino Diabet &amp;amp; Metabol"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Identifying people with diabetes who are likely to experience a foot ulcer is an important part of preventative care. Many cohort studies report predictive models for foot ulcerations and for people with diabetes, but reports of long\u2010term outcomes are scarce.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>We aimed to develop a predictive model for foot ulceration in diabetes using a range of potential risk factors with a follow\u2010up of 10\u2009years after recruitment. A new foot ulceration was the outcome of interest and death was the secondary outcome of interest.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A 10\u2010year follow\u2010up cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>1193 people with a diagnosis of diabetes who took part in a study in 2006\u20132007 were invited to participate in a 10\u2010year follow\u2010up. We developed a prognostic model for the incidence of incident foot ulcerations using a survival analysis, Cox proportional hazards model. We also utilised survival analysis Kaplan\u2013Meier curves, and relevant tests, to assess the association between the predictor variables for foot ulceration and death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 10\u2010year follow\u2010up, 41% of the original study population had died and more than 18% had developed a foot ulcer. The predictive factors for foot ulceration were an inability to feel a 10\u2009g monofilament or vibration from a tuning fork, previous foot ulceration and duration of diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The prognostic model shows an increased risk of ulceration for those with previous history of foot ulcerations, insensitivity to a 10\u2009g monofilament, a tuning fork and duration of diabetes. The incidence of foot ulceration at 10\u2010year follow\u2010up was 18%; however, the risk of death for this community\u2010based population was far greater than the risk of foot ulceration.<\/jats:p><\/jats:sec>","DOI":"10.1002\/edm2.459","type":"journal-article","created":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T23:49:46Z","timestamp":1700783386000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The 10\u2010year follow\u2010up of a community\u2010based cohort of people with diabetes: The incidence of foot ulceration and death"],"prefix":"10.1002","volume":"7","author":[{"given":"Shijat Ali","family":"Mohammed","sequence":"first","affiliation":[{"name":"School of Mathematics and Statistics University of St Andrews  St Andrews UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0473-9959","authenticated-orcid":false,"given":"Fay","family":"Crawford","sequence":"additional","affiliation":[{"name":"School of Health and Social Care University of Essex  Colchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Genevieve Isabelle","family":"Cezard","sequence":"additional","affiliation":[{"name":"British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care University of Cambridge  Cambridge UK"},{"name":"Victor Phillip Dahdaleh Heart and Lung Research Institute University of Cambridge  Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michail","family":"Papathomas","sequence":"additional","affiliation":[{"name":"School of Mathematics and Statistics University of St Andrews  St Andrews UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,21]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"International Diabetes Federation IDF Diabetes Atlas.10th edn. Brussels Belgium.2021. Accessed October 29 2023.https:\/\/www.diabetesatlas.org"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.13973"},{"key":"e_1_2_12_4_1","unstructured":"NICE NG19.Diabetic Foot Problems Prevention and Management. Accessed October 29 2023.https:\/\/www.nice.org.uk\/guidance\/ng19"},{"key":"e_1_2_12_5_1","unstructured":"International Working Group of the Diabetic Foot (IWGDF). Accessed October 29 2023.https:\/\/iwgdfguidelines.org\/"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-021-05448-w"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2017.02.034"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta19570"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.14339"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.13054"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcq227"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta24620"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-77244-8_11"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-3462-1"},{"volume-title":"Eds Kirkwood and Sterne","year":"2003","author":"Essential Medical Statistics","key":"e_1_2_12_15_1"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.7992"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.2299"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1586\/17512433.1.3.391"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2016.08.62"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1201\/9781003282525"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.2.217"},{"key":"e_1_2_12_22_1","unstructured":"Life Expectancy in Scottish Areas.National Registers of Scotland. Accessed October 29 2023.https:\/\/www.nrscotland.gov.uk\/statistics\u2010and\u2010data\/statistics\/statistics\u2010by\u2010theme\/life\u2010expectancy\/life\u2010expectancy\u2010in\u2010scottish\u2010areas"}],"container-title":["Endocrinology, Diabetes &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/edm2.459","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T06:56:28Z","timestamp":1706165788000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/edm2.459"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,21]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1002\/edm2.459"],"URL":"https:\/\/doi.org\/10.1002\/edm2.459","archive":["Portico"],"relation":{},"ISSN":["2398-9238","2398-9238"],"issn-type":[{"type":"print","value":"2398-9238"},{"type":"electronic","value":"2398-9238"}],"subject":[],"published":{"date-parts":[[2023,11,21]]},"assertion":[{"value":"2023-07-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e459"}}