{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T18:23:26Z","timestamp":1785781406380,"version":"3.56.0"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T00:00:00Z","timestamp":1710201600000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012806","name":"High Point University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012806","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Endocrino Diabet &amp;amp; Metabol"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Sodium glucose\u2010linked transporter 2 (SGLT2) inhibitors promote glucose, and therefore calorie, excretion in the urine. Patients taking SGLT2 inhibitors typically experience mild weight loss, but the amount of weight loss falls short of what is expected based on caloric loss. Understanding the mechanisms responsible for this weight loss discrepancy is imperative, as strategies to improve weight loss could markedly improve type 2 diabetes management and overall metabolic health.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two mouse models of diet\u2010induced obesity were administered the SGLT2 inhibitor empagliflozin in the food for 3\u2009months. Urine glucose excretion, body weight, food intake and activity levels were monitored. In addition, serum hormone measurements were taken, and gene expression analyses were conducted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In both mouse models, mice receiving empagliflozin gained the same amount of body weight as their diet\u2010matched controls despite marked glucose loss in the urine. No changes in food intake, serum ghrelin concentrations or activity levels were observed, but serum levels of fibroblast growth factor 21 (FGF21) decreased after treatment. A decrease in the levels of deiodinase 2 (Dio2) was also observed in the white adipose tissue, a primary target tissue of FGF21.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings suggest that compensatory metabolic adaptations, other than increased food intake or decreased physical activity, occur in response to SGLT2 inhibitor\u2010induced glycosuria that combats weight loss, and that reductions in FGF21, along with subsequent reductions in peripheral Dio2, may play a role.<\/jats:p><\/jats:sec>","DOI":"10.1002\/edm2.475","type":"journal-article","created":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T05:55:04Z","timestamp":1710309304000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effects of Empagliflozin\u2010Induced Glycosuria on Weight Gain, Food Intake and Metabolic Indicators in Mice Fed a High\u2010Fat Diet"],"prefix":"10.1002","volume":"7","author":[{"given":"Anh T.","family":"Nguyen","sequence":"first","affiliation":[{"name":"Fred Wilson School of Pharmacy High Point University  High Point North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary","family":"Amigo","sequence":"additional","affiliation":[{"name":"Fred Wilson School of Pharmacy High Point University  High Point North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"McDuffie","sequence":"additional","affiliation":[{"name":"Fred Wilson School of Pharmacy High Point University  High Point North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria C.","family":"MacQueen","sequence":"additional","affiliation":[{"name":"Fred Wilson School of Pharmacy High Point University  High Point North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lane D.","family":"Bell","sequence":"additional","affiliation":[{"name":"Fred Wilson School of Pharmacy High Point University  High Point North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan K.","family":"Truong","sequence":"additional","affiliation":[{"name":"Fred Wilson School of Pharmacy High Point University  High Point North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Batchi","sequence":"additional","affiliation":[{"name":"Fred Wilson School of Pharmacy High Point University  High Point North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1298-3767","authenticated-orcid":false,"given":"Sara M.","family":"McMillin","sequence":"additional","affiliation":[{"name":"Fred Wilson School of Pharmacy High Point University  High Point North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,12]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"Centers for Disease Control and Prevention National Diabetes Statistics Report Website. 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