{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T06:29:31Z","timestamp":1780468171488,"version":"3.54.1"},"reference-count":54,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,31]],"date-time":"2024-03-31T00:00:00Z","timestamp":1711843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100020481","name":"Shahid Beheshti University","doi-asserted-by":"publisher","award":["74859"],"award-info":[{"award-number":["74859"]}],"id":[{"id":"10.13039\/100020481","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Endocrino Diabet &amp;amp; Metabol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The <jats:italic>FTO<\/jats:italic> gene polymorphisms may influence the effects of lifestyle interventions on obesity. The present study aimed to assess the influence of the rs9930506 <jats:italic>FTO<\/jats:italic> gene polymorphism on the success of a comprehensive weight loss intervention in male adolescents with overweight and obesity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study was carried out on 96 adolescent boys with overweight and obesity who were randomly assigned to the intervention (<jats:italic>n<\/jats:italic>\u2009=\u200953) and control (<jats:italic>n<\/jats:italic>\u2009=\u200943) groups. The blood samples of the participants were collected, and the <jats:italic>FTO<\/jats:italic> gene was genotyped for the rs9930506 polymorphism. A comprehensive lifestyle intervention including changes in diet and physical activity was performed for 8\u2009weeks in the intervention group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Following the lifestyle intervention, BMI and fat mass decreased significantly in the intervention group compared with the control group (both <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), while no change was found in weight, height or body muscle percentage between the groups. The participants in the intervention group with the AA\/AG genotype and not in carriers of the GG genotype had a significantly higher reduction in BMI (\u22121.21 vs. 1.87\u2009kg\/m<jats:sup>2<\/jats:sup>, <jats:italic>F<\/jats:italic>\u2009=\u20094.07, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) compared with the control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The intervention in individuals with the AA\/AG genotype has been significantly effective in weight loss compared with the control group. The intervention had no association effect on anthropometric indices in adolescents with the GG genotype of the <jats:italic>FTO<\/jats:italic> rs9930506 polymorphism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial Registration<\/jats:title><jats:p>Name of the registry: National Nutrition and Food Technology Research Institute; Trial registration number: IRCT2016020925699N2; Date of registration: 24\/04\/2016; URL of trial registry record: <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.irct.ir\/trial\/21447\">https:\/\/www.irct.ir\/trial\/21447<\/jats:ext-link><\/jats:p><\/jats:sec>","DOI":"10.1002\/edm2.483","type":"journal-article","created":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T04:39:24Z","timestamp":1711946364000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Efficacy of a Comprehensive Weight Reduction Intervention in Male Adolescents With Different <scp>FTO<\/scp> Genotypes"],"prefix":"10.1002","volume":"7","author":[{"given":"Zahra","family":"Roumi","sequence":"first","affiliation":[{"name":"Department of Nutrition, Science and Research Branch Islamic Azad University  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Salimi","sequence":"additional","affiliation":[{"name":"Nutrition and Metabolic Diseases Research Center Ahvaz Jundishapur University of Medical Sciences  Ahvaz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Mahmoudi","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Science and Research Branch Islamic Azad University  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khadijeh Abbasi","family":"Mobarakeh","sequence":"additional","affiliation":[{"name":"Food Security Research Center and Department of Community Nutrition, School of Nutrition and Food Science Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Ladaninezhad","sequence":"additional","affiliation":[{"name":"School of Nutritional Sciences and Dietetics Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mobina","family":"Zeinalabedini","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Keshavarz\u00a0Mohammadian","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Science and Research Branch Islamic Azad University  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Shamsi\u2010Goushki","sequence":"additional","affiliation":[{"name":"Department of Nutrition, School of Medicine Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Saeedirad","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition and Dietetics Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bojlul","family":"Bahar","sequence":"additional","affiliation":[{"name":"Nutrition Sciences and Applied Food Safety Studies, Research Centre for Global Development, School of Sport &amp; 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