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The aim of this study was to investigate the effects of high\u2010fat diet (HFD) and psychological stress combination on metabolic response to chronic psychological stress in male rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Male Wistar rats were divided into HFD, and normal diet (ND) groups and then into stress and nonstress subgroups. The diets were applied for 5\u2009weeks, and psychological stress was induced for 7 consecutive days. Then, blood samples were taken to measure glucose, insulin, free fatty acids (FFA), and leptin and corticosterone concentrations. Subsequently, glucose\u2010stimulated insulin release from pancreatic isolated islets was assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>HFD did not significantly change fasting plasma glucose, insulin and corticosterone levels, whereas increased plasma leptin (7.05\u2009\u00b1\u20090.33) and FFA (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) levels and impaired glucose tolerance. Additionally, HFD and stress combination induced more profound glucose intolerance associated with increased plasma corticosterone (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) and leptin (8.63\u2009\u00b1\u20090.38) levels. However, insulin secretion from isolated islets did not change in the presence of high\u2010fat diet and\/or stress.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>HFD should be considered as an intensified factor of metabolic impairments caused by chronic psychological stress.<\/jats:p><\/jats:sec>","DOI":"10.1002\/edm2.487","type":"journal-article","created":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T04:07:15Z","timestamp":1718251635000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Metabolic Responses to <scp>High\u2010Fat<\/scp> Feeding and Chronic Psychological Stress Combination"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1227-0847","authenticated-orcid":false,"given":"Marzieh","family":"Nemati","sequence":"first","affiliation":[{"name":"Department of Physiology, School of Medicine Shahid Beheshti University of Medical Sciences  Tehran Iran"},{"name":"Endocrinology and Metabolism Research Center Shiraz University of Medical Science  Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatemeh","family":"Rostamkhani","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Basic Sciences, Yadegar\u2010e\u2010Imam Khomeini (RAH) Branch Islamic Azad University  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roxana","family":"Karbaschi","sequence":"additional","affiliation":[{"name":"Faculty of Nursing and Midwifery Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8307-1848","authenticated-orcid":false,"given":"Homeira","family":"Zardooz","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Medicine Shahid Beheshti University of Medical Sciences  Tehran Iran"},{"name":"Neurophysiology Research Center Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,6,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1999.277.4.E659"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.40.2.166"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2021.0280"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1969.00300130081012"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1119406"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-127-4-1580"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.133.1.8319569"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00401761"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117042"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-005-4943-9"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.46.2.313"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.84.2.5460"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.46.6.1087"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1996.1059"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0022814"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI9842"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119171"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.2000.279.6.E1374"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00230.2001"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-2220"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-020496"},{"volume-title":"Endocrine and Reproductive Physiology","year":"2007","author":"Porterfield S. 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