{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:40:44Z","timestamp":1786977644244,"version":"build-2736575974"},"reference-count":68,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T00:00:00Z","timestamp":1716163200000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Endocrino Diabet &amp;amp; Metabol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to investigate whether polycystic ovary syndrome (PCOS) status changes the association between insulin resistance (IR) indices and liver function parameters among women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a cross\u2010sectional, population\u2010based study. We selected 1101 subjects aged \u226520\u2009years from participants of Tehran Lipid and Glucose Study (TLGS). All of them had known the status of PCOS, and all variables were related to the IR indices and liver function parameters. The main outcome measures were TG\/HDL\u2010C and triglyceride\u2010glucose (TyG) and liver function parameters (hepatic steatosis index [HSI], alanine transaminase [ALT] and aspartate transaminase [AST]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>\n                      In the present study, there was no significant difference between the PCOS and the non\u2010PCOS regarding the presence of liver function abnormalities. A model adjusted by age and BMI showed that the upper tertile of TyG index was positively associated with high AST (OR\u2009=\u20093.04 [95% CI: 1.20\u20137.68],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), high ALT (4.76 [3.07\u20137.36],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) and high HSI (8.44 [1.82\u201339.17],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Although the history of diabetes had a positive impact on elevated AST (1.66 [1.15, 2.40],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), the third tertile of TG\/HDL\u2010C was associated with increased odds of elevated ALT (3.35 [2.21\u20135.06]) and HSI (6.55 [1.17\u201336.46]), whereas the second tertile of TG\/HDL\u2010C (OR\u2009=\u20092.65, CI 95%: 1.74\u20134.03) was also positively associated with elevated ALT. PCOS had no significant association with elevated liver function tests.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The highest tertile of TyG index and the TG\/HDL\u2010C ratio as a surrogate of IR might play a role in detecting abnormalities of liver function parameters among women. However, PCOS status cannot change the association between IR and liver dysfunction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/edm2.490","type":"journal-article","created":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T01:16:24Z","timestamp":1716254184000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Association Between Insulin Resistance Indices and Liver Function Parameters Among Women With Polycystic Ovary Syndrome"],"prefix":"10.1002","volume":"7","author":[{"given":"Marzieh","family":"Saei\u00a0Ghare\u00a0Naz","sequence":"first","affiliation":[{"name":"Reproductive Endocrinology Research Center Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Mousavi","sequence":"additional","affiliation":[{"name":"Reproductive Endocrinology Research Center Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faezeh","family":"Firouzi","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir\u00a0Abbas","family":"Momenan","sequence":"additional","affiliation":[{"name":"Prevention of Metabolic Disorders Research Center Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6470-2517","authenticated-orcid":false,"given":"Fereidoun","family":"Azizi","sequence":"additional","affiliation":[{"name":"Endocrine Research Center Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4609-065X","authenticated-orcid":false,"given":"Fahimeh","family":"Ramezani\u00a0Tehrani","sequence":"additional","affiliation":[{"name":"Reproductive Endocrinology Research Center Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences  Tehran Iran"},{"name":"The Foundation for Research &amp; Education Excellence  Vestaria Hills AI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,20]]},"reference":[{"key":"e_1_2_12_2_1","volume-title":"StatPearls [Internet]","author":"Freeman A. 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