{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T22:59:09Z","timestamp":1774306749907,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T00:00:00Z","timestamp":1720742400000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Endocrino Diabet &amp;amp; Metabol"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Sellar masses are common intracranial neoplasms. Their clinical manifestations vary widely and include headache. We aimed to determine whether the prevalence and characteristics of headache in patients with sellar tumours differ from the general population and to investigate the effect of tumour resection on this complaint.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a prospective, controlled study in a single tertiary centre and included 57 patients that underwent transsphenoidal resection for a sellar mass (53% females, mean age 53.5\u2009\u00b1\u200916.4) and 29 of their partners (controls; 45% females, mean age 54.8\u2009\u00b1\u200914.9). Outcome measures were prevalence, characteristics and impact of headache 1\u2009month preoperatively and at neurosurgical follow\u2010up 3\u2009months postoperatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Preoperatively, the prevalence of regular headache (\u22651 time per month) was higher in patients than in controls (54% vs. 17%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and patients scored higher on headache impact questionnaires (all <jats:italic>p<\/jats:italic>\u2009\u2264\u20090.01). At postoperative follow\u2010up, headache prevalence decreased in both groups, but the decrease in regular headache frequency and impact was larger in patients than in controls, and no between\u2010group differences remained.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>More than half of patients with sellar tumours suffer from at least once\u2010monthly headaches, and both regular headache occurrence and impact are higher compared with controls. The more pronounced decrease in headache complaints in patients versus controls at postoperative follow\u2010up suggests an additional effect of tumour resection next to the factor time.<\/jats:p><\/jats:sec>","DOI":"10.1002\/edm2.496","type":"journal-article","created":{"date-parts":[[2024,7,13]],"date-time":"2024-07-13T05:44:36Z","timestamp":1720849476000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Controlled Study of Pre\u2010 and Postoperative <scp>Headache<\/scp> in Patients with Sellar Masses (<scp>HEADs<\/scp>\u2010<scp>uP<\/scp> Study)"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2890-754X","authenticated-orcid":false,"given":"Tessa\u00a0N.\u00a0A.","family":"Slagboom","sequence":"first","affiliation":[{"name":"Department of Endocrinology &amp; Metabolism Amsterdam UMC Location Vrije Universiteit Amsterdam  Amsterdam The Netherlands"},{"name":"Pituitary Centre Amsterdam  Amsterdam The Netherlands"},{"name":"Amsterdam Gastroenterology Endocrinology and Metabolism  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tessel\u00a0M.","family":"Boertien","sequence":"additional","affiliation":[{"name":"Pituitary Centre Amsterdam  Amsterdam The Netherlands"},{"name":"Amsterdam Gastroenterology Endocrinology and Metabolism  Amsterdam The Netherlands"},{"name":"Department of Endocrinology &amp; Metabolism Amsterdam UMC Location University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter\u00a0H.","family":"Bisschop","sequence":"additional","affiliation":[{"name":"Pituitary Centre Amsterdam  Amsterdam The Netherlands"},{"name":"Amsterdam Gastroenterology Endocrinology and Metabolism  Amsterdam The Netherlands"},{"name":"Department of Endocrinology &amp; Metabolism Amsterdam UMC Location University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Fliers","sequence":"additional","affiliation":[{"name":"Pituitary Centre Amsterdam  Amsterdam The Netherlands"},{"name":"Amsterdam Gastroenterology Endocrinology and Metabolism  Amsterdam The Netherlands"},{"name":"Department of Endocrinology &amp; Metabolism Amsterdam UMC Location University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes\u00a0C.","family":"Baaijen","sequence":"additional","affiliation":[{"name":"Pituitary Centre Amsterdam  Amsterdam The Netherlands"},{"name":"Department of Neurosurgery Amsterdam UMC Location University of Amsterdam  Amsterdam The Netherlands"},{"name":"Amsterdam Neuroscience  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jantien","family":"Hoogmoed","sequence":"additional","affiliation":[{"name":"Pituitary Centre Amsterdam  Amsterdam The Netherlands"},{"name":"Department of Neurosurgery Amsterdam UMC Location University of Amsterdam  Amsterdam The Netherlands"},{"name":"Amsterdam Neuroscience  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madeleine\u00a0L.","family":"Drent","sequence":"additional","affiliation":[{"name":"Department of Endocrinology &amp; Metabolism Amsterdam UMC Location Vrije Universiteit Amsterdam  Amsterdam The Netherlands"},{"name":"Pituitary Centre Amsterdam  Amsterdam The Netherlands"},{"name":"Amsterdam Gastroenterology Endocrinology and Metabolism  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/cjn.2015.301"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nos218"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2015.02.006"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12314"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.5.1789"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3171\/2015.5.JNS1576"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1851-5017"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-022-01402-2"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2007.01288.x"},{"issue":"3","key":"e_1_2_9_11_1","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1002\/cncr.20412","article-title":"The Prevalence of Pituitary Adenomas: A Systematic Review","volume":"101","author":"Ezzat S.","year":"2004","journal-title":"Cancer: Interdisciplinary International Journal of the American Cancer Society"},{"issue":"60","key":"e_1_2_9_12_1","first-page":"1235","article-title":"Frequency of Pituitary Adenoma Among the Patients With Chronic Headache","volume":"33","author":"Mahesar M. 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