{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T23:48:20Z","timestamp":1788392900912,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,6,16]],"date-time":"2024-06-16T00:00:00Z","timestamp":1718496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008091","name":"Golestan University of Medical Sciences","doi-asserted-by":"publisher","award":["112063"],"award-info":[{"award-number":["112063"]}],"id":[{"id":"10.13039\/501100008091","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Endocrino Diabet &amp;amp; Metabol"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Diabetes mellitus (DM) is a chronic metabolic disorder characterised by high blood sugar (BS) levels due to impaired insulin production or insulin resistance. It is a global health concern with significant implications for morbidity and mortality. Persian medicine has long utilised natural remedies, such as <jats:italic>Pistacia atlantica<\/jats:italic> Desf., for various diseases. In this randomised clinical trial, the effects of <jats:italic>P.\u2009atlantica<\/jats:italic> oleoresin in the improvement of lipid profiles, glucose indices and blood pressure (BP) were assessed in patients with Type 2 DM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>In this randomised, single\u2010blind, placebo\u2010controlled study, 42 patients with Type 2 DM were randomly allocated to receive either <jats:italic>P.\u2009atlantica<\/jats:italic> oleoresin or placebo capsule for 3\u2009months. Patients were evaluated prior to and 12\u2009weeks after the beginning of the intervention, in terms of changes in lipid profiles, glucose indices and BP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After 3 months, the mean BP in patients with DM receiving <jats:italic>P.\u2009atlantica<\/jats:italic> oleoresin was significantly reduced compared with the baseline (<jats:italic>p<\/jats:italic>\u2009=\u20090.001). Also, these changes were significantly higher than those of the control group. The mean of total cholesterol (<jats:italic>p<\/jats:italic>\u2009=\u20090.89), low\u2010density lipoprotein (LDL) (<jats:italic>p<\/jats:italic>\u2009=\u20090.43) and triglyceride (TG) (<jats:italic>p<\/jats:italic>\u2009=\u20090.98) in the intervention group after 3 months was lower than that in the control group, but this difference was not statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>After 3 months, there was no significant difference between the <jats:italic>P.\u2009atlantica<\/jats:italic> and control groups in terms of blood sugar and lipid profiles. The mean BP in patients with DM receiving <jats:italic>P.\u2009atlantica<\/jats:italic> oleoresin was significantly reduced compared with that in the beginning of the study. Also, these changes were significant compared with the control group.<\/jats:p><\/jats:sec>","DOI":"10.1002\/edm2.504","type":"journal-article","created":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T06:08:54Z","timestamp":1718604534000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of the Effect of <i>Pistacia atlantica<\/i> Oleoresin on Blood Sugar, Pressure and Lipids in Patients With Type 2 Diabetes: A Single\u2010Blind, Placebo\u2010Controlled Trial"],"prefix":"10.1002","volume":"7","author":[{"given":"Zahra","family":"Memariani","sequence":"first","affiliation":[{"name":"Pharmaceutical Sciences Research Center Babol University of Medical Sciences  Babol Iran"},{"name":"Traditional Medicine and History of Medical Sciences Research Center, Health Research Institute Babol University of Medical Sciences  Babol Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahin","family":"Tatari","sequence":"additional","affiliation":[{"name":"Statistical Science Department Sapienza University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Zahedi","sequence":"additional","affiliation":[{"name":"Clinical Research Development Unit (CRDU) Golestan University of Medical Sciences  Gorgan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5399-8631","authenticated-orcid":false,"given":"Zahra","family":"Hesari","sequence":"additional","affiliation":[{"name":"Laboratory Sciences Research Center Golestan University of Medical Sciences  Gorgan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Davarian","sequence":"additional","affiliation":[{"name":"Ischemic Disorders Research Center Golestan University of Medical Science  Gorgan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3310-5103","authenticated-orcid":false,"given":"Fatemeh","family":"Kolangi","sequence":"additional","affiliation":[{"name":"Counseling and Reproductive Health Research Centre, Department of Persian Medicine, School of Medicine Golestan University of Medical Sciences  Gorgan Iran"},{"name":"Food, Drug, Natural Products Health Research Centre GolestanUniversity of Medical Sciences  Gorgan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,16]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00580-015-2068-1"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2017.11.049"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.2018.1482577"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13098-021-00704-w"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/endrev\/bnaa025"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctim.2004.09.007"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-815354-3.00004-6"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S250417"},{"key":"e_1_2_12_10_1","volume-title":"Makhzan ul\u2010Advia","author":"Aghili A. 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