{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T13:36:07Z","timestamp":1785332167187,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,10,2]],"date-time":"2024-10-02T00:00:00Z","timestamp":1727827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007436","name":"Torben og Alice Frimodts Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007436","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006197","name":"Fonden til L\u00e6gevidenskabens Fremme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006197","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Endocrino Diabet &amp;amp; Metabol"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Tumour necrosis factor (TNF)\u2010\u03b1 is a proinflammatory marker and has been shown to affect mitochondrial function in different tissues. We investigated the effect on adipose tissue (AT) inflammation and mitochondrial respiration in patients with hidradenitis suppurativa (HS) after 12\u2009weeks of treatment with adalimumab, a TNF\u2010\u03b1 inhibitor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We sampled blood and an AT biopsy from 13 patients with HS and 10 control subjects after an overnight fast. The patients were retested after at least 12\u2009weeks of treatment with adalimumab (40\u2009mg\/week). We measured macrophage content and mitochondrial respiration in the AT and interleukin (IL)\u20101\u03b2, IL\u20106, IL\u201010, high\u2010sensitivity C\u2010reactive protein (hsCRP), interferon\u2010\u03b3, TNF\u2010\u03b1, adiponectin and leptin in plasma. Clinical scores and Dermatology Quality of Life Index (DLQI) were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found a higher anti\u2010inflammatory macrophage content (CD206<jats:sup>+<\/jats:sup>) in the patient group compared with the control group, but no differences between before and after the intervention. No difference in mitochondrial respiration was observed. We observed higher plasma IL\u20106 and hsCRP concentrations in patients with HS compared to controls, with no differences before and after the intervention. The difference between controls and HS patients was abolished after the intervention. HS patients improved their DLQI after the intervention with no change in clinical scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Treatment with adalimumab in patients with HS does not alter AT inflammation or mitochondrial respiratory capacity; however, we did see a higher content of anti\u2010inflammatory macrophages in the patient group compared with the control group.<\/jats:p><\/jats:sec>","DOI":"10.1002\/edm2.70002","type":"journal-article","created":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T04:54:16Z","timestamp":1727931256000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Adalimumab Treatment Effects on Inflammation and Adipose Tissue Mitochondrial Respiration in Hidradenitis Suppurativa"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7276-2384","authenticated-orcid":false,"given":"Ronni\u00a0Eg","family":"Sahl","sequence":"first","affiliation":[{"name":"Xlab, Center for Healthy Aging, Department of Biomedical Sciences, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3978-9857","authenticated-orcid":false,"given":"Axel\u00a0Illeris","family":"Poggi","sequence":"additional","affiliation":[{"name":"Xlab, Center for Healthy Aging, Department of Biomedical Sciences, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7395-6009","authenticated-orcid":false,"given":"Valdemar\u00a0Wendelboe","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of 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