{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:58:52Z","timestamp":1787068732328,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T00:00:00Z","timestamp":1739404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100019779","name":"Qatar National Library","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019779","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UM1TR004400"],"award-info":[{"award-number":["UM1TR004400"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Endocrino Diabet &amp;amp; Metabol"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Idiopathic intracranial hypertension (IIH) is a neurological disorder characterised by elevated intracranial pressure (ICP), predominantly affecting obese women of reproductive age. While GLP\u20101 receptor agonists have shown promise in IIH management, the potential of dual GIP\/GLP\u20101 receptor activation through tirzepatide remains unexplored. This study aimed to evaluate tirzepatide's efficacy as an adjunctive therapy in IIH management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective cohort analysis using the TriNetX Global Health Research Network, analysing data through November 2024. Through propensity score matching, we compared 193 tirzepatide\u2010exposed IIH patients with 193 controls receiving standard care. Primary outcomes included papilledema severity, visual function, headache frequency, and treatment resistance, monitored at multiple follow\u2010up timepoints.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Our analysis revealed significant improvements across all measured outcomes in the tirzepatide group. At 24\u2009months, we observed a 68% reduction in papilledema risk (RR 0.320, 95% CI 0.189\u20130.542,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), a 73.9% reduction in visual disturbance and blindness risk (RR 0.261, 95% CI 0.143\u20130.477,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and a 19.7% reduction in headache risk (RR 0.803, 95% CI 0.668\u20130.966,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.019). The tirzepatide group demonstrated significant body\u2010mass index reductions, reaching \u22121.147\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      (95% CI [\u22121.415, \u22120.879],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) at 24\u2009months compared to controls.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our results demonstrate that tirzepatide, when used as an adjunctive therapy, provides significant therapeutic benefits in IIH management, particularly in improving papilledema and visual outcomes. Our findings suggest that dual GIP\/GLP\u20101 receptor activation may offer advantages over traditional single\u2010receptor therapies, potentially through enhanced metabolic regulation and direct effects on ICP dynamics.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/edm2.70019","type":"journal-article","created":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T01:39:46Z","timestamp":1739497186000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Efficacy of Tirzepatide Dual\n                    <scp>GIP<\/scp>\n                    \/\n                    <scp>GLP<\/scp>\n                    \u20101 Receptor Agonist in Patients With Idiopathic Intracranial Hypertension. A Real\u2010World Propensity Score\u2010Matched Study"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4256-0159","authenticated-orcid":false,"given":"Ahmed Y.","family":"Azzam","sequence":"first","affiliation":[{"name":"Montefiore\u2010Einstein Cerebrovascular Research Lab Albert Einstein College of Medicine  Bronx New York USA"},{"name":"Department of Neurological Surgery, Montefiore Medical Center Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammed Amir","family":"Essibayi","sequence":"additional","affiliation":[{"name":"Montefiore\u2010Einstein Cerebrovascular Research Lab Albert Einstein College of Medicine  Bronx New York USA"},{"name":"Department of Neurological Surgery, Montefiore Medical Center Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Farkas","sequence":"additional","affiliation":[{"name":"Department of Radiology, Montefiore Medical Center Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed A.","family":"Azab","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Cleveland Clinic Foundation  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud M.","family":"Morsy","sequence":"additional","affiliation":[{"name":"October 6 University Hospital, October 6 University  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osman","family":"Elamin","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Jordan Hospital  Amman Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Elswedy","sequence":"additional","affiliation":[{"name":"Biomedicinskt Centrum BMC Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed Saad","family":"Al Zomia","sequence":"additional","affiliation":[{"name":"College of Medicine, King Khalid University  Abha Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hammam A.","family":"Alotaibi","sequence":"additional","affiliation":[{"name":"Ophthalmology Department Prince Sultan Military Medical City  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Alamoud","sequence":"additional","affiliation":[{"name":"College of Medicine, King Khalid University  Abha Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oday","family":"Atallah","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7993-7467","authenticated-orcid":false,"given":"Hana J.","family":"Abukhadijah","sequence":"additional","affiliation":[{"name":"Medical Research Center, Hamad Medical Corporation  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam A.","family":"Dmytriw","sequence":"additional","affiliation":[{"name":"Neuroendovascular Program, Massachusetts General Hospital &amp; Brigham and Women's Hospital Harvard University  Boston Massachusetts USA"},{"name":"Neurovascular Centre, Divisions of Therapeutic Neuroradiology &amp; Neurosurgery, St. Michael's Hospital University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Baker","sequence":"additional","affiliation":[{"name":"Montefiore\u2010Einstein Cerebrovascular Research Lab Albert Einstein College of Medicine  Bronx New York USA"},{"name":"Department of Neurological Surgery, Montefiore Medical Center Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak","family":"Khatri","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Montefiore Medical Center Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Haranhalli","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Montefiore Medical Center Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Altschul","sequence":"additional","affiliation":[{"name":"Montefiore\u2010Einstein Cerebrovascular Research Lab Albert Einstein College of Medicine  Bronx New York USA"},{"name":"Department of Neurological Surgery, Montefiore Medical Center Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,13]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.37349\/eds.2023.00015"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awad003"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.14895"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNO.0000000000000684"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-024-01821-3"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2024.122948"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/CPJ.0000000000001063"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-023-01631-z"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jamiaopen\/ooad035"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15913"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102416650705"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/13543784.2023.2288073"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.145346"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.27010"},{"issue":"4","key":"e_1_2_12_16_1","first-page":"375","article-title":"Understanding the Pathophysiology of Idiopathic Intracranial Hypertension (IIH): A Review of Recent Developments","volume":"95","author":"Colman B. 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