{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T08:36:51Z","timestamp":1790757411784,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T00:00:00Z","timestamp":1736899200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["1K08DK109116"],"award-info":[{"award-number":["1K08DK109116"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008269","name":"Michigan Institute for Clinical and Health Research","doi-asserted-by":"publisher","award":["U064177"],"award-info":[{"award-number":["U064177"]}],"id":[{"id":"10.13039\/100008269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Endocrino Diabet &amp;amp; Metabol"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Context<\/jats:title><jats:p>Hyperandrogenism is a hallmark of polycystic ovary syndrome (PCOS), yet the androgen(s) responsible remain ambiguous. Recent studies have suggested that 11\u2010oxygenated C<jats:sub>19<\/jats:sub> steroids (11\u2010oxyandrogens), specifically 11\u2010ketotestosterone, may be a good marker for hyperandrogenism in PCOS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the utility of 11\u2010oxyandrogens to differentiate women with and without PCOS relative to classical androgens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design Setting<\/jats:title><jats:p>Case\u2013control study performed at a PCOS clinic and research center in an academic setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>114 women with PCOS and 78 healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interventions<\/jats:title><jats:p>Using the PCOS Tissue Bank, serum samples and data from 114 women registered from 2013 to 2017 between the ages of 18\u201340\u2009years, were obtained and classified using Rotterdam PCOS criteria. Data were compared to 78 healthy women of similar age, with serum samples obtained between 2017 and 2020. 11\u2010oxyandrogens and sex steroids were measured using mass spectrometry, and their associations to Rotterdam PCOS, age, and BMI were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>11\u2010oxyandrogens and sex steroids.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Total testosterone, androstenedione, and four 11\u2010oxyandrogens were significantly elevated in women with PCOS compared to age matched controls, controlling for age and BMI (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01 for all). When considered together, the four 11\u2010oxyandrogens were more predictive of PCOS compared to testosterone and androstenedione. When all androgens were considered individually, 11\u2010ketoandrostenedione was the most predictive of PCOS. Of the six androgens studied, 11\u2010ketotestosterone was the only androgen that demonstrated a weak association with hirsutism score (<jats:italic>r<\/jats:italic>\u2009=\u20090.17; <jats:italic>p<\/jats:italic>\u2009=\u20090.07) within the PCOS group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>11\u2010oxyandrogens were statistically higher in women with PCOS and may serve as better predictors of PCOS than testosterone and androstenedione.<\/jats:p><\/jats:sec>","DOI":"10.1002\/edm2.70022","type":"journal-article","created":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T06:40:50Z","timestamp":1737009650000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Exploring the Predictive Role of 11\u2010Oxyandrogens in Diagnosing Polycystic Ovary Syndrome"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6341-0144","authenticated-orcid":false,"given":"Armaiti Parvez","family":"Mody","sequence":"first","affiliation":[{"name":"Division of Pediatric Endocrinology University of California  Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3188-377X","authenticated-orcid":false,"given":"Maya Beth","family":"Lodish","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard Joseph","family":"Auchus","sequence":"additional","affiliation":[{"name":"Division of Metabolism, Endocrinology and Diabetes University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adina F.","family":"Turcu","sequence":"additional","affiliation":[{"name":"Division of Metabolism, Endocrinology and Diabetes University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Jiang","sequence":"additional","affiliation":[{"name":"Division of Epidemiology &amp; Biostatistics University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather Gibson","family":"Huddleston","sequence":"additional","affiliation":[{"name":"Division of Reproductive Endocrinology and Infertility University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,15]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP15748.DSCPT2"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/jhrs.JHRS_95_18"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dew218"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-2350"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13389"},{"key":"e_1_2_11_7_1","first-page":"4589","article-title":"11\u2010Ketotestosterone Is the Dominant Circulating Bioactive Androgen During Normal and Premature Adrenarche","volume":"103","author":"Rege J.","year":"2018","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-15-1181"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2016.08.014"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)55317-5"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2016-3285"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-2912"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0159867"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2013.07.006"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa343"},{"key":"e_1_2_11_16_1","volume-title":"Polycystic Ovary Syndrome","author":"Dunaif A.","year":"1992"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13795"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-19-0905"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-12-77"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ18-0212"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2017-00947"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2019-01357"}],"container-title":["Endocrinology, Diabetes &amp; 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