{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T10:31:55Z","timestamp":1768041115203,"version":"3.49.0"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T00:00:00Z","timestamp":1739836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Endocrino Diabet &amp;amp; Metabol"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Polycystic ovary syndrome (PCOS) is one of the commonest gyneco\u2010endocrine disorders amongst women of reproductive age. Whether PCOS and cardiometabolic traits in PCOS patients are associated with shortened telomere length (TL) or relative leukocyte telomere length (rLTL) remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>214 women with PCOS and 214 age\u2010matched women were recruited. rLTL was measured with an updated quantitative real\u2010time PCR protocol and reported as \u0394\u0394Ct between telomere and a single\u2010copy gene encoding \u03b2\u2010globin relative to a normalisation control. A two\u2010way Mendelian randomization analysis using the UK Biobank Resource was performed to assess the causal relationship between rLTL and PCOS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Women with PCOS had significantly shortened rLTL (PCOS: 0.5\u2009\u00b1\u20090.7; control: 0.8\u2009\u00b1\u20090.6; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Longer rLTL was associated with a lower risk of PCOS after adjusting for age, history of smoking and other cardiometabolic traits (OR: 0.503; 95% CI: 0.342\u20130.730; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Longer rLTL was associated with reduced risk of dyslidpidemia (OR: 0.563; 95% CI: 0.450\u20130.968; <jats:italic>p<\/jats:italic>\u2009=\u20090.042) in PCOS patients. PCOS subjects with rLTL shorter than mean of the rLTL of control subjects had an elevated risk of dysglycemia (OR: 2.09; 95% CI: 1.04\u20134.29; <jats:italic>p<\/jats:italic>\u2009=\u20090.040). No causal relationships were found between rLTL and PCOS in the Mendelian randomization study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Women with PCOS have significantly reduced rLTL and shorter LTL may be associated with cardiometabolic risk factors in PCOS subjects. There are no causal relationship between genetically determined PCOS and TL or vice versa.<\/jats:p><\/jats:sec>","DOI":"10.1002\/edm2.70030","type":"journal-article","created":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T08:35:22Z","timestamp":1739867722000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Shortened Relative Leukocyte Telomere Length Is Associated With Polycystic Ovary Syndrome and Metabolic Traits"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1678-9128","authenticated-orcid":false,"given":"Raymond N.C.","family":"Chan","sequence":"first","affiliation":[{"name":"Department of Medicine and Therapeutics The Chinese University of Hong Kong, Prince of Wales Hospital  Hongkong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3442-4760","authenticated-orcid":false,"given":"Chuiguo","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics The Chinese University of Hong Kong, Prince of Wales Hospital  Hongkong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4186-7113","authenticated-orcid":false,"given":"Noel Y. H.","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics The Chinese University of Hong Kong, Prince of Wales Hospital  Hongkong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2708-8253","authenticated-orcid":false,"given":"Henry C. H.","family":"Tam","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics The Chinese University of Hong Kong, Prince of Wales Hospital  Hongkong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9169-0013","authenticated-orcid":false,"given":"Claudia H. T.","family":"Tam","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics The Chinese University of Hong Kong, Prince of Wales Hospital  Hongkong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3234-513X","authenticated-orcid":false,"given":"Feifei","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics The Chinese University of Hong Kong, Prince of Wales Hospital  Hongkong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwun Kiu","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics The Chinese University of Hong Kong, Prince of Wales Hospital  Hongkong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2798-3268","authenticated-orcid":false,"given":"Mai","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics The Chinese University of Hong Kong, Prince of Wales Hospital  Hongkong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex C. W.","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics The Chinese University of Hong Kong, Prince of Wales Hospital  Hongkong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4132-7084","authenticated-orcid":false,"given":"Atta Y. T.","family":"Tsang","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics The Chinese University of Hong Kong, Prince of Wales Hospital  Hongkong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3928-7278","authenticated-orcid":false,"given":"Chi Chiu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology The Chinese University of Hong Kong, Prince of Wales Hospital  Hongkong China"},{"name":"Li Ka Shing Institute of Health Sciences The Chinese University of Hong Kong  Hongkong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3829-8546","authenticated-orcid":false,"given":"Lai Ping","family":"Cheung","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology The Chinese University of Hong Kong, Prince of Wales Hospital  Hongkong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1189-740X","authenticated-orcid":false,"given":"Wing Hung","family":"Tam","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology The Chinese University of Hong Kong, Prince of Wales Hospital  Hongkong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5346-2266","authenticated-orcid":false,"given":"Mugdha V.","family":"Joglekar","sequence":"additional","affiliation":[{"name":"Diabetes and Islet Biology Group, School of Medicine Western Sydney University  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5587-2090","authenticated-orcid":false,"given":"Anandwardhan A.","family":"Hardikar","sequence":"additional","affiliation":[{"name":"Diabetes and Islet Biology Group, School of Medicine Western Sydney University  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0583-3717","authenticated-orcid":false,"given":"Alicia J.","family":"Jenkins","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics The Chinese University of Hong Kong, Prince of Wales Hospital  Hongkong China"},{"name":"Baker Heart and Diabetes Institute  Melbourne Victoria Australia"},{"name":"NHMRC Clinical Trial Centre, Faculty of Medicine and Health University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1325-1194","authenticated-orcid":false,"given":"Juliana C. 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