{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T07:12:45Z","timestamp":1788246765647,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T00:00:00Z","timestamp":1742947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Endocrino Diabet &amp;amp; Metabol"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Considering recent revisions in the nomenclature for fatty liver disease, alongside limited data on sex\u2010specific differences in its cardiovascular\/mortality outcomes, this study aims to investigate the prevalence and impact of metabolic\u2010associated fatty liver disease (MAFLD) on cardiovascular disease (CVD) and mortality in men and women over a 12\u2010year follow\u2010up period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this large population\u2010based cohort study, 7101 individuals aged \u2265\u200930 were enrolled. The prevalence of MAFLD was investigated in both genders. After excluding individuals with a history of previous CVD, 6331 participants were followed up for CVD and mortality over 12\u2009years. Steatosis was defined as fatty liver index (FLI) \u2265\u200960. Multivariate\u2010adjusted hazard ratios (HRs) were calculated for CVD and mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The prevalence of MAFLD was 43.2%, higher in men (46.5%) than women (40.6%). Men with MAFLD (47.7\u2009\u00b1\u200912.1) were younger than women (52.2\u2009\u00b1\u200911.1). In the 12\u2010year follow\u2010up of 6331 individuals, multivariable\u2010adjusted CVD HRs for MAFLD were 1.36 (1.10\u20131.67) in men and 1.48 (1.16\u20131.88) in women. Adjusted mortality HRs were 1.17 (0.86\u20131.59) and 1.38 (1.00\u20131.91) in men and women, respectively. Among patients with MAFLD, a subgroup with diabetes faced the highest hazard for CVD and mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study found that MAFLD is more common in men at a younger age. Despite the higher prevalence in men, women with MAFLD face a greater risk of cardiovascular events and mortality. Findings highlight the importance of gender\u2010specific considerations in primary prevention programmes for MAFLD\u2010related cardiovascular disease and mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/edm2.70035","type":"journal-article","created":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T14:10:26Z","timestamp":1743257426000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Sex\u2010Specific Impact of Metabolic Dysfunction\u2010Associated Fatty Liver Disease on Incident Cardiovascular Diseases and Mortality"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2748-6111","authenticated-orcid":false,"given":"Mahsa","family":"Abbaszadeh","sequence":"first","affiliation":[{"name":"Endocrinology and Metabolism Research Center Imam Khomeini Hospital Complex, Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farhad","family":"Hosseinpanah","sequence":"additional","affiliation":[{"name":"Obesity Research Center Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Science  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Tohidi","sequence":"additional","affiliation":[{"name":"Prevention of Metabolic Disorders Research Center Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2669-6942","authenticated-orcid":false,"given":"Sahar","family":"Karimpour Reyhan","sequence":"additional","affiliation":[{"name":"Endocrinology and Metabolism Research Center Imam Khomeini Hospital Complex, Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Mahdavi","sequence":"additional","affiliation":[{"name":"Obesity Research Center Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Science  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majid","family":"Valizadeh","sequence":"additional","affiliation":[{"name":"Obesity Research Center Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Science  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,26]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14521"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2309000"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.03.039"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000520"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgac321"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.05.013"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30626"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2020.04.067"},{"issue":"4","key":"e_1_2_12_10_1","article-title":"Review of Rationale, Design, and Initial Findings: Tehran Lipid and Glucose Study","volume":"16","author":"Azizi F.","year":"2018","journal-title":"International Journal of Endocrinology and Metabolism"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.13.4.401"},{"issue":"5","key":"e_1_2_12_12_1","first-page":"279","article-title":"Reliability and Validity of the Modifiable Activity Questionnaire (MAQ) in an Iranian Urban Adult Population","volume":"15","author":"Momenan A. 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