{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:49:45Z","timestamp":1753868985596,"version":"3.41.2"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T00:00:00Z","timestamp":1745280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["TL1TR003106"],"award-info":[{"award-number":["TL1TR003106"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Endocrino Diabet &amp;amp; Metabol"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Incidence of type 2 diabetes mellitus (T2DM) and obesity is increasing in children. We aimed to observe the metabolic health effects of glucagon\u2010like peptide 1 (GLP\u20101) receptor agonists in paediatric patients with T2DM in a real\u2010world setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective chart review of patients aged 0 to 18\u2009years with T2DM who were started on a GLP\u20101 receptor agonist between August 2019 and August 2023 and followed for up to 24 months was included in this study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>321 patients were included in the analysis. After 12\u2009months of treatment with a GLP\u20101 receptor agonist, haemoglobin A1c (HbA1c) was reduced by \u22121.04%\u2009\u00b1\u20092.3% (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). At 24 months, HbA1c was similar to baseline (8.3%\u2009\u00b1\u20092.5% vs. 7.9%\u2009\u00b1\u20092.5%, <jats:italic>p<\/jats:italic>\u2009=\u20090.24). There was a significant (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) decrease in the use of metformin, basal insulin, and bolus insulin at one year which was sustained at the two\u2010year follow\u2010up for metformin (<jats:italic>p<\/jats:italic>\u2009=\u20090.002). Overall, there was no significant change in BMI nor other metabolic parameters while undergoing treatment with a GLP\u20101 receptor agonist.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Paediatric patients with T2DM using GLP\u20101 receptor agonists experienced a significant decrease in HbA1c after 12\u2009months of use, which was not sustained at 24\u2009months. However, patients had a reduction in insulin and metformin use at 12\u2009months. No significant impact was appreciated on BMI or other metabolic variables.<\/jats:p><\/jats:sec>","DOI":"10.1002\/edm2.70053","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T12:38:54Z","timestamp":1748349534000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of <scp>GLP<\/scp>\u20101 Receptor Agonists on Paediatric Population in a Real World Setting"],"prefix":"10.1002","volume":"8","author":[{"given":"A. G.","family":"Barajas","sequence":"first","affiliation":[{"name":"University of Alabama at Birmingham Marnix E. Heersink School of Medicine  Birmingham Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles A.","family":"Gagnon\u2010Vargas","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham Marnix E. Heersink School of Medicine  Birmingham Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0733-2000","authenticated-orcid":false,"given":"Jessica A.","family":"Schmitt","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics University of Alabama at Birmingham Marnix E. 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