{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T15:51:08Z","timestamp":1785253868107,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,7,13]],"date-time":"2025-07-13T00:00:00Z","timestamp":1752364800000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Endocrino Diabet &amp;amp; Metabol"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Procalcitonin (PCT) is an effective inflammatory marker for diagnosing infection. We assessed the clinical utility of procalcitonin in diagnosing diabetic foot infections.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This meta\u2010analysis adhered to the PRISMA guidelines. We searched PubMed, Web of Science, Embase and the Cochrane Library for studies on PCT for the diagnosis of diabetic foot published before 1 July 2024. The primary outcome was the standardised mean difference (SMD) in PCT levels between IDFU and non\u2010IDFU groups, with corresponding 95% confidence intervals (CI). The included studies were cross\u2010sectional and cohort studies, so the quality of the literature was assessed using the Newcastle\u2013Ottawa Scale (NOS) evaluation criteria. This study's statistical analyses were conducted solely with STATA 15.0 software.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>Ten studies comprising 928 patients were ultimately included. There were six cross\u2010sectional studies and four cohort studies. In total, 532 patients were assigned to the IDFU group and 396 to the non\u2010infected diabetic foot ulcers (NIDFU) group. The relationship between PCT and DFU was evaluated in ten studies, with significant heterogeneity among the included studies (<jats:italic>x<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200954.10, <jats:italic>p\u2009=<\/jats:italic> 0.00001; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200983.6%). Therefore, a random effects model was used with a pooled standardised mean difference of 0.79 (95% confidence interval [CI]: 0.43\u20131.14). The Egger experiment results (<jats:italic>t<\/jats:italic>\u2009=\u20090.43, <jats:italic>p<\/jats:italic>\u2009=\u20090.680) indicated that there was no publication bias. Analysis of sensitivity revealed that the results were reliable. Subgroup analyses identified the area as a significant source of heterogeneity. The random\u2010effects model's meta\u2010regression results revealed that BMI (<jats:italic>p<\/jats:italic>\u2009=\u20090.026) and HbA1c (<jats:italic>p<\/jats:italic>\u2009=\u20090.016) had a significant impact on the heterogeneity of the association between IDFU and PCT levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study showed a significant correlation between serum PCT levels and IDFU. Identification and treatment of IDFUs as soon as possible can help reduce amputation and mortality rates.<\/jats:p><jats:p>This systematic review and meta\u2010analysis evaluated the association between serum procalcitonin levels and diabetic foot infections. Ten studies were included, and a random\u2010effects model showed significantly higher procalcitonin levels in infected patients, supporting its role as a potential diagnostic biomarker for early infection detection in diabetic foot ulcers.<\/jats:p><\/jats:sec>","DOI":"10.1002\/edm2.70066","type":"journal-article","created":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T06:50:25Z","timestamp":1752475825000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Procalcitonin and Diabetic Foot Ulcer Infections: A Meta\u2010Analysis"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9438-4871","authenticated-orcid":false,"given":"Wenqiang","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Bone and Joint Surgery (Guangxi Diabetic Foot Salvage Engineering Research Center\/Research Centre for Regenerative Medicine) The First Affiliated Hospital of Guangxi Medical University  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4980-0582","authenticated-orcid":false,"given":"Peilin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Bone and Joint Surgery (Guangxi Diabetic Foot Salvage Engineering Research Center\/Research Centre for Regenerative Medicine) The First Affiliated Hospital of Guangxi Medical University  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Nie","sequence":"additional","affiliation":[{"name":"Department of Bone and Joint Surgery (Guangxi Diabetic Foot Salvage Engineering Research Center\/Research Centre for Regenerative Medicine) The First Affiliated Hospital of Guangxi Medical University  Nanning China"},{"name":"Department of Orthopedics The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qikai","family":"Hua","sequence":"additional","affiliation":[{"name":"Department of Bone and Joint Surgery (Guangxi Diabetic Foot Salvage Engineering Research Center\/Research Centre for Regenerative Medicine) The First Affiliated Hospital of Guangxi Medical University  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2019.107843"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2016.1231932"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2022.110194"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/2042018817744513"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13569"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0141076816688346"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/dci22\u20100043"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2017.04.008"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijem.IJEM_525_18"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654\u2010010\u20109491\u2010z"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2017.02.060"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010007\u20100840\u20108"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12545"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.5704\/moj.2307.010"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.5812\/ijem.13376"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/15347346211011849"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/23744235.2019.1688387"},{"issue":"1","key":"e_1_2_9_19_1","first-page":"77","article-title":"Is Procalcitonin More Superior to Hs\u2010CRP in the Diagnosis of Infection in Diabetic Foot Ulcer?","volume":"42","author":"Zakariah N. 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