{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T14:45:58Z","timestamp":1784126758801,"version":"3.55.0"},"reference-count":97,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T00:00:00Z","timestamp":1758412800000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Endocrino Diabet &amp;amp; Metabol"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Systemic lupus erythematosus (SLE) is a chronic autoimmune disease primarily affecting women of childbearing age, characterised by relapsing inflammation across multiple organ systems. Its aetiology involves genetic and environmental factors that trigger immune dysregulation, leading to the excessive release of autoantibodies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study discusses the pathogenesis, diagnosis, management and emerging therapeutic targets in SLE, with a focus on metabolic reprogramming and the role of obesity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Diagnosis is based on clinical and laboratory findings, with the EULAR and ACR criteria being the most advanced. SLE management requires individualised treatment, addressing the severity and organs affected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>SLE presents with symptoms ranging from mild skin rashes to severe conditions like pulmonary hypertension and kidney failure. Advances in care have improved outcomes, with 80%\u201390% of patients achieving normal life expectancy with proper treatment. Metabolic reprogramming in immune cells is crucial to SLE pathogenesis, as altered glycolysis and fatty acid oxidation contribute to inflammation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Obesity is recognised to aggravate SLE by fostering chronic inflammation, immunological dysregulation and dysbiosis of the gut microbiota. These situations may exacerbate autoimmunity, especially in genetically predisposed individuals. It is suggested that obesity significantly contributes to the pathogenesis of SLE, and additional study should investigate metabolic therapy aimed at obesity and microbiota to re\u2010establish immunological equilibrium and mitigate disease development.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Targeting metabolic pathways may offer new therapeutic options for improved disease management. Particular abnormalities in gut microbiota, characterised by reduced diversity and an increase in pro\u2010inflammatory species, influence obesity\u2010related immunological dysregulation in systemic lupus erythematosus and may present new therapeutic targets.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/edm2.70077","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T05:56:02Z","timestamp":1758520562000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Unveiling Molecular Mechanisms Underlying Obesity\u2010Associated Systemic Lupus Erythematosus"],"prefix":"10.1002","volume":"8","author":[{"given":"Roshvin Kailashnath","family":"Pillai","sequence":"first","affiliation":[{"name":"Faculty of Medicine MAHSA University  Jenjarom Selangor Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rishvini Kailashnath","family":"Pillai","sequence":"additional","affiliation":[{"name":"Faculty of Medicine MAHSA University  Jenjarom Selangor Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinibha","family":"Rajakumari Illankovan","sequence":"additional","affiliation":[{"name":"Centre for Pre\u2010University Studies MAHSA University  Jenjarom Selangor Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinod","family":"Balasubramaniam","sequence":"additional","affiliation":[{"name":"Jeffrey Cheah School of Medicine and Health Sciences Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway  Subang Jaya Selangor Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. M.","family":"Alabsi","sequence":"additional","affiliation":[{"name":"Management and Science University University Drive, Off Persiaran Olahraga  Shah Alam Selangor Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anupam","family":"Biswas","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Physiology AIMST University  Bedong Kedah Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hari Kumar","family":"Darnal","sequence":"additional","affiliation":[{"name":"International Medical School Management and Science University  Shah Alam Selangor Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saminathan","family":"Kayarohanam","sequence":"additional","affiliation":[{"name":"Faculty of Bioeconomics, Food &amp; Health Science University Geomatika Malaysia, Prima Peninsula  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhan Kumar Soutallu","family":"Janakiram","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Faculty of Medicine Manipal University College  Bukit Baru Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vetriselvan","family":"Subramaniyan","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Sir Jeffrey Cheah Sunway Medical School Faculty of Medical and Life Sciences Sunway University  Subang Jaya Selangor Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,21]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01139\u201020"},{"key":"e_1_2_12_3_1","volume-title":"Systemic Lupus Erythematosus","author":"Justiz Vaillant A. 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