{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:28:46Z","timestamp":1790267326557,"version":"4.1.0"},"reference-count":66,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:00:00Z","timestamp":1756944000000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Endocrino Diabet &amp;amp; Metabol"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Lipid accumulation product (LAP) index is a measure of lipid toxicity based on triglyceride and waist circumference. The aim of the current study is to explore the relationship between LAP index and metabolic syndrome (MetS) among women with polycystic ovary syndrome (PCOS) in a systematic review and meta\u2010analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Web of Science, Embase and PubMed online databases were systematically searched for studies investigating the relationship between LAP index and MetS in PCOS. Ten observational studies, including 12 populations with 2957 individuals, were identified for analysis. Mean difference and bivariate diagnostic test accuracy (DTA) meta\u2010analyses were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A significant LAP index difference of 49.17 was found in women with PCOS with and without MetS (95% CI [40.57, 57.77]). By DTA meta\u2010analysis, the pooled sensitivity and specificity of LAP index for MetS detection were 87% (\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      78%, 95% CI [80%, 92%]) and 88% (\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      78%, 95% CI [83%, 92%]), respectively, with area under the curve of 0.94 (95% CI [0.91, 0.96]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The LAP index is an affordable, specific and sensitive marker for MetS and may be considered a pragmatic tool for MetS detection among patients with PCOS, particularly those with an insulin resistance endotype.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/edm2.70078","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T04:54:56Z","timestamp":1757048096000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Lipid Accumulation Product Index as a Marker of Metabolic Syndrome in Women With Polycystic Ovary Syndrome: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1504-3893","authenticated-orcid":false,"given":"Seyed Arsalan","family":"Seyedi","sequence":"first","affiliation":[{"name":"Endocrinology and Metabolism Research Center (EMRC), Vali\u2010Asr Hospital, Imam Khomeini Hospital  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Ali","family":"Nabipoorashrafi","sequence":"additional","affiliation":[{"name":"Endocrinology and Metabolism Research Center (EMRC), Vali\u2010Asr Hospital, Imam Khomeini Hospital  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samira","family":"Amin Afshari","sequence":"additional","affiliation":[{"name":"Endocrinology and Metabolism Research Center (EMRC), Vali\u2010Asr Hospital, Imam Khomeini Hospital  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afsoun","family":"Mansouri","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Pharmaceutical Sciences, Islamic Azad University of Tehran Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9885-5397","authenticated-orcid":false,"given":"Dorsa","family":"Alizadegan","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Ayatollah Amoli Branch, Islamic Azad University  Amol Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Hobaby","sequence":"additional","affiliation":[{"name":"School of Medicine, Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Esmaeilpur Abianeh","sequence":"additional","affiliation":[{"name":"Universal Scientific Education and Research Network (USERN), Tehran  Iran"},{"name":"School of Medicine, Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey I.","family":"Mechanick","sequence":"additional","affiliation":[{"name":"Marie\u2010Jos\u00e9e and Henry R. 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