{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T18:45:35Z","timestamp":1754160335579,"version":"3.41.2"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,7,26]],"date-time":"2025-07-26T00:00:00Z","timestamp":1753488000000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Endocrino Diabet &amp;amp; Metabol"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Diabetes mellitus is the most prevalent endocrine disorder in individuals under 30\u2009years, encompassing type 1 diabetes mellitus (T1DM), early\u2010onset type 2 diabetes mellitus (T2DM), monogenic diabetes, and maturity\u2010onset diabetes of the young (MODY). This study investigated the prevalence, types, and complications associated with early\u2010onset diabetes (EOD) in the Upper East Region of Ghana.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study used anonymised patient data from the Ghana Health Service's electronic data system, focusing on inpatient records of individuals aged 0 to 30 diagnosed with diabetes. After removing personal identifiers, incomplete records, gestational diabetes cases, and duplicates, the dataset included variables such as age, sex, education level, admission year, outcomes, diagnoses, and complications, but lacked laboratory and treatment information.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of EOD among patients under 30\u2009years of age was calculated to be 0.16% (52 out of 33,282). T1DM was diagnosed in 15 out of 52 patients (28.8%), while only one case of T2DM was identified. Secondary diabetes due to unknown etiologies was the most common diagnosis (22 out of 52 cases, 42.3%), indicating the potential presence of undiagnosed monogenic diabetes or MODY. Reported complications included diabetic foot (5 cases), diabetic nephropathy (2 cases), infections (4 cases), retinopathy (4 cases), and ketoacidosis (13 cases). The data showed 3 deaths, 1 referral, and 1 absconded case were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings highlight the need for accurate diagnosis, targeted management strategies, and further research into secondary diabetes and its potential underlying causes in Ghana. Improved diagnostic capabilities, awareness, and healthcare resources are essential to address EOD and its complications at the study site.<\/jats:p><\/jats:sec>","DOI":"10.1002\/edm2.70079","type":"journal-article","created":{"date-parts":[[2025,7,26]],"date-time":"2025-07-26T08:19:11Z","timestamp":1753517951000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Early\u2010Onset Diabetes in Ghana's Upper East Region\u2014Insights From Hospital Data"],"prefix":"10.1002","volume":"8","author":[{"given":"Solomon","family":"Beletaa","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Medicine School of Medicine, University for Development Studies  Tamale Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ceasar","family":"Kaba","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Medicine School of Medicine, University for Development Studies  Tamale Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joy Afua","family":"Mensah","sequence":"additional","affiliation":[{"name":"College of Health Sciences University of Ghana  Accra Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1468-301X","authenticated-orcid":false,"given":"Gideon Kofi","family":"Helegbe","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Medicine School of Medicine, University for Development Studies  Tamale Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1871-8048","authenticated-orcid":false,"given":"James","family":"Abugri","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Forensic Sciences School of Chemical and Biochemical Sciences, C. 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Tedam University of Technology and Applied Sciences  Navrongo Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1993-2786","authenticated-orcid":false,"given":"Samuel Mawuli","family":"Adadey","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Medicine School of Medicine, University for Development Studies  Tamale Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,26]]},"reference":[{"key":"e_1_2_13_2_1","unstructured":"AMA ADA \u201cAmerican Diabetes Association Releases 2023 Standards of Care in Diabetes to Guide Prevention Diagnosis and Treatment for People Living With Diabetes \u201dhttps:\/\/diabetes.org\/newsroom\/american\u2010diabetes\u2010association\u20102023\u2010standards\u2010care\u2010diabetes\u2010guide\u2010for\u2010prevention\u2010diagnosis\u2010treatment\u2010people\u2010living\u2010with\u2010diabetes."},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2021.109118"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010023\u201006085\u20101"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2023.2182909"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-41559-8_3"},{"key":"e_1_2_13_7_1","unstructured":"CDC \u201cNational Diabetes Statistics Report \u201d (2024) https:\/\/www.cdc.gov\/diabetes\/php\/data\u2010research\/index.html."},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.7196\/sajch.500"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20108587(22)00218\u20102"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.21608\/jbaar.2024.382794"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.4103\/1118-8561.121910"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12902\u2010023\u201001468\u20102"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.803992"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-010-9151-3"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.4274\/jcrpe.galenos.2020.2020.0093"},{"key":"e_1_2_13_16_1","doi-asserted-by":"crossref","unstructured":"P.TheofilouandD. 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