{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T07:26:11Z","timestamp":1793085971169,"version":"4.5.0"},"reference-count":194,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T00:00:00Z","timestamp":1758067200000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Endocrino Diabet &amp;amp; Metabol"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Erectile dysfunction (ED) is a highly prevalent complication of diabetes mellitus (DM), significantly impairing quality of life and psychosocial well\u2010being. The prevalence of ED is estimated to be over 3.5 times higher in men with diabetes mellitus compared to those without. The aetiology of diabetic ED is multifactorial, stemming from complex diabetes mellitus\u2010related systemic changes. The pathophysiology of diabetic ED involves interacting pathways, including endothelial dysfunction, accelerated atherosclerosis, autonomic and peripheral neuropathy, structural penile changes, hormonal imbalances, and psychological factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A review of the literature was conducted to examine the pathophysiological mechanisms, genetic associations, and treatment modalities related to diabetic ED. Particular attention was given to studies exploring pharmacogenetics and emerging therapeutic interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Management is multimodal, including lifestyle changes, counselling, and pharmacological agents (primarily phosphodiesterase type 5 inhibitors (PDE5Is)), but treatment response varies. Genetic studies have identified associations between ED risk\/severity and polymorphisms in several candidate genes, including\n                      <jats:italic>NOS3<\/jats:italic>\n                      (G894T, T786C, VNTR),\n                      <jats:italic>ARG1\/ARG2<\/jats:italic>\n                      (influencing nitric oxide substrate availability), ACE (I\/D polymorphism),\n                      <jats:italic>AR<\/jats:italic>\n                      (CAG repeat length affecting androgen sensitivity), and\n                      <jats:italic>VEGF<\/jats:italic>\n                      (promoter polymorphisms). Pharmacogenetic studies suggest that polymorphisms in\n                      <jats:italic>NOS3<\/jats:italic>\n                      ,\n                      <jats:italic>AR<\/jats:italic>\n                      , and\n                      <jats:italic>VEGF<\/jats:italic>\n                      may predict response to PDE5Is or testosterone therapy, while\n                      <jats:italic>ARG1\/ARG2<\/jats:italic>\n                      variations might guide future arginase\u2010targeted therapies. Emerging treatments like low\u2010intensity shockwave therapy, platelet\u2010rich plasma, gene therapy, and stem cell therapy show promise but require more robust evidence.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Diabetic ED is a complex condition driven by multiple pathophysiological mechanisms often influenced by an underlying genetic predisposition. Understanding the interplay between pathophysiology and genetics is crucial for developing personalised treatment strategies. While current therapies offer benefits, variability in response highlights the need for tailored approaches. Further research, especially large\u2010scale pharmacogenetic studies and randomised controlled trials for emerging therapies, is essential to identify reliable biomarkers, optimise treatment selection, and improve outcomes for men with diabetic ED.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/edm2.70099","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T11:30:47Z","timestamp":1758108647000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Erectile Dysfunction in Diabetes Mellitus: A Comprehensive Narrative Review of Pathophysiology, Genetic Association Studies and Therapeutic Approaches"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1251-7161","authenticated-orcid":false,"given":"Bo\u0161tjan","family":"Hostnik","sequence":"first","affiliation":[{"name":"Division of Internal Medicine, Department of Endocrinology, Diabetes and Metabolic Diseases University Medical Centre Ljubljana  Ljubljana Slovenia"},{"name":"Faculty of Medicine University of Ljubljana  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8268-1695","authenticated-orcid":false,"given":"Ga\u0161per","family":"Tonin","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Ljubljana  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrej","family":"Jane\u017e","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine, Department of Endocrinology, Diabetes and Metabolic Diseases University Medical Centre Ljubljana  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8807-7242","authenticated-orcid":false,"given":"Jasna","family":"Klen","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Ljubljana  Ljubljana Slovenia"},{"name":"Division of Surgery, Department of Abdominal Surgery University Medical Centre Ljubljana  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.13403"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3494"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2021.109119"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.08.023"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/nmj.NMJ_225_16"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/RRU.S283097"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.2165\/00019053-200220020-00004"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsm.12601"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1394383"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.21.11.1973"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-020-09541-0"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsm.12495"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41443-020-00405-4"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000026326"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2009.01624.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/372231a0"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ucl.2005.08.007"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1139\/o91-119"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2000.t01-2-00177.x"},{"key":"e_1_2_9_21_1","first-page":"465","volume-title":"The Autonomic Nervous System","author":"De Groat W.","year":"1993"},{"issue":"1","key":"e_1_2_9_22_1","first-page":"S25","article-title":"Central Control of Penile Erection","volume":"10","author":"McKenna K. E.","year":"1998","journal-title":"International Journal of Impotence Research"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(93)90179-J"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijir.3900396"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci13050802"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2024.1368079"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijir.2012.30"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms13020250"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.21873\/invivo.12531"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-97-6406-8_14"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes15121596"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2016.23"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2005.20103.x"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1006\/niox.2001.0394"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0705293"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.033990"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsxm.2019.04.004"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijir.3900270"},{"issue":"3","key":"e_1_2_9_39_1","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/S0022-5347(01)67730-9","article-title":"PGE1 Suppresses the Induction of Collagen Synthesis by Transforming Growth Factor\u2010Beta 1 in Human Corpus Cavernosum Smooth Muscle","volume":"153","author":"Moreland R. B.","year":"1995","journal-title":"Journal of Urology"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.03.051"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc20-0654"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.10.069"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.21037\/tau-20-999"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001250051227"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2007.01.054"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1179\/016164101101198965"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2006.01911.x"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2008.01168.x"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.111.004515"},{"issue":"1","key":"e_1_2_9_50_1","first-page":"88","article-title":"The Treatment of Erectile Dysfunction in Patients With Neurogenic Disease","volume":"5","author":"Shridharani A. N.","year":"2016","journal-title":"Translational Andrology and Urology"},{"issue":"1","key":"e_1_2_9_51_1","article-title":"Neurogenic Erectile Dysfunction. Where Do We Stand?","volume":"8","author":"Thomas C.","year":"2021","journal-title":"Medicines (Basel)"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.sc.3101978"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.1980.tb02962.x"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.4103\/aja202293"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.21037\/tau-21-13"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.12546"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2020.07.015"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-017-4245-z"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijir.2016.40"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/scientificamerican0587-90"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(87)90069-4"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)63311-1"},{"issue":"2","key":"e_1_2_9_63_1","doi-asserted-by":"crossref","DOI":"10.1002\/edm2.195","article-title":"Fibroproliferative Disorders and Diabetes: Understanding the Pathophysiologic Relationship Between Peyronie's Disease, Dupuytren Disease and Diabetes","volume":"4","author":"Gelbard M. K.","year":"2020","journal-title":"Endocrinology, Diabetes & Metabolism"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1177\/000331970505600208"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijir.2011.44"},{"issue":"6","key":"e_1_2_9_66_1","first-page":"384","article-title":"Dupuytren's Disease: Predicting Factors and Associated Conditions. A Single Center Questionnaire\u2010Based Case\u2010Control Study","volume":"5","author":"Morelli I.","year":"2017","journal-title":"Archives of Bone and Joint Surgery"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-94025-7"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.4103\/UA.UA_164_18"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1177\/03000605221100334"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2018.00157"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.12411"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-018-8763-5"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-017-9805-9"},{"issue":"7","key":"e_1_2_9_74_1","first-page":"602","article-title":"Hypothalamus May Be Involved in Psychogenic Erectile Dysfunction","volume":"14","author":"Wang T.","year":"2008","journal-title":"Zhonghua Nan Ke Xue = National Journal of Andrology"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0105336"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2017.00221"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0039118"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-7967(86)90145-2"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1430143"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00368189"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.2147\/PPA.S99544"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2004.03.010"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2008.00907.x"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9136(199601)13:1<84::AID-DIA16>3.0.CO;2-A"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000053241.06172.95"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmedr.2019.100822"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsxm.2018.05.007"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.4103\/jhrs.jhrs_60_24"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389450118666170315110902"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jadr.2024.100750"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.17712\/nsj.2020.1.20190058"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2016.11.033"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.5534\/wjmh.180045"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1156757"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2021.111214"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1177\/0748730411416341"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41585-020-00376-7"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2007.10.024"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsxm.2020.06.009"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-0637"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.13977"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.12705"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.11.1288"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-022-09748-3"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsxm.2016.06.004"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(00)00667-1"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.2164\/jandrol.109.008730"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2010.01991.x"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.4103\/2230-8229.122006"},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.4081\/aiua.2022.4.464"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.3803\/EnM.2014.29.3.300"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-1649"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2016-3580"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.12425"},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018-00229"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-022-01788-5"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.12669\/pjms.343.14330"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2009.06.063"},{"key":"e_1_2_9_119_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2156-11-54"},{"key":"e_1_2_9_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sxmr.2020.05.005"},{"key":"e_1_2_9_121_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsm.12896"},{"key":"e_1_2_9_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2018.04.012"},{"key":"e_1_2_9_123_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2010.01968.x"},{"key":"e_1_2_9_124_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12013-015-0540-9"},{"key":"e_1_2_9_125_1","doi-asserted-by":"publisher","DOI":"10.4103\/1008-682X.163300"},{"key":"e_1_2_9_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsxm.2017.02.003"},{"key":"e_1_2_9_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2015.10.003"},{"key":"e_1_2_9_128_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2001.4874"},{"key":"e_1_2_9_129_1","doi-asserted-by":"publisher","DOI":"10.1517\/17460441.2014.949234"},{"key":"e_1_2_9_130_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2011.02499.x"},{"key":"e_1_2_9_131_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2010.02098.x"},{"key":"e_1_2_9_132_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsm.12134"},{"key":"e_1_2_9_133_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10225407"},{"key":"e_1_2_9_134_1","doi-asserted-by":"publisher","DOI":"10.1080\/17520363.2025.2455924"},{"key":"e_1_2_9_135_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0072277"},{"key":"e_1_2_9_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2011.12.076"},{"key":"e_1_2_9_137_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijir.3901598"},{"key":"e_1_2_9_138_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2010.01796.x"},{"key":"e_1_2_9_139_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0272.2009.00975.x"},{"key":"e_1_2_9_140_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2047-2927.2012.00029.x"},{"key":"e_1_2_9_141_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0272.2010.01125.x"},{"key":"e_1_2_9_142_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsm.12790"},{"key":"e_1_2_9_143_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2605.2011.01220.x"},{"key":"e_1_2_9_144_1","doi-asserted-by":"publisher","DOI":"10.1097\/XCE.0000000000000230"},{"key":"e_1_2_9_145_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.12068"},{"key":"e_1_2_9_146_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-023-02131-2"},{"key":"e_1_2_9_147_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.13507"},{"key":"e_1_2_9_148_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijir.2008.1"},{"key":"e_1_2_9_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.12.226"},{"key":"e_1_2_9_150_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.16927"},{"key":"e_1_2_9_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsxm.2017.02.009"},{"key":"e_1_2_9_152_1","doi-asserted-by":"publisher","DOI":"10.1177\/15579883241282385"},{"key":"e_1_2_9_153_1","doi-asserted-by":"publisher","DOI":"10.1038\/tpj.2012.39"},{"key":"e_1_2_9_154_1","doi-asserted-by":"publisher","DOI":"10.1093\/sexmed\/qfae090"},{"key":"e_1_2_9_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsxm.2016.05.017"},{"key":"e_1_2_9_156_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.13506"},{"key":"e_1_2_9_157_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijir.3900472"},{"key":"e_1_2_9_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(97)00238-0"},{"key":"e_1_2_9_159_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2012.02735.x"},{"key":"e_1_2_9_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sxmr.2018.10.005"},{"key":"e_1_2_9_161_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41443-018-0032-8"},{"key":"e_1_2_9_162_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2012.02825.x"},{"key":"e_1_2_9_163_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10508-012-0062-0"},{"key":"e_1_2_9_164_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2011.440"},{"key":"e_1_2_9_165_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsxm.2016.01.016"},{"key":"e_1_2_9_166_1","doi-asserted-by":"publisher","DOI":"10.1136\/postgradmedj-2016-134073"},{"key":"e_1_2_9_167_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11237214"},{"key":"e_1_2_9_168_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2010.02062.x"},{"key":"e_1_2_9_169_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3629"},{"key":"e_1_2_9_170_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.111128"},{"key":"e_1_2_9_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2015.05.037"},{"key":"e_1_2_9_172_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.01.012"},{"key":"e_1_2_9_173_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03349261"},{"key":"e_1_2_9_174_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2008.01118.x"},{"key":"e_1_2_9_175_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000132798.48067.23"},{"key":"e_1_2_9_176_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-4295(91)80314-W"},{"key":"e_1_2_9_177_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2009.01627.x"},{"key":"e_1_2_9_178_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)40208-4"},{"key":"e_1_2_9_179_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1148834\/full"},{"key":"e_1_2_9_180_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOU.0000000000000442"},{"key":"e_1_2_9_181_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsxm.2019.07.016"},{"key":"e_1_2_9_182_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41443-019-0117-z"},{"key":"e_1_2_9_183_1","doi-asserted-by":"publisher","DOI":"10.1093\/sxmrev\/qead032"},{"key":"e_1_2_9_184_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546517746112"},{"key":"e_1_2_9_185_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2023.01.028"},{"key":"e_1_2_9_186_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)36059-7"},{"key":"e_1_2_9_187_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijir.2010.4"},{"key":"e_1_2_9_188_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsxm.2016.09.008"},{"key":"e_1_2_9_189_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijir.2015.33"},{"key":"e_1_2_9_190_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ucl.2011.02.009"},{"key":"e_1_2_9_191_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sxmr.2018.03.007"},{"key":"e_1_2_9_192_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsxm.2020.06.012"},{"key":"e_1_2_9_193_1","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.2010.510510"},{"key":"e_1_2_9_194_1","doi-asserted-by":"publisher","DOI":"10.1590\/s1677-5538.ibju.2024.0100"},{"key":"e_1_2_9_195_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ucl.2021.06.014"}],"container-title":["Endocrinology, Diabetes &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/edm2.70099","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T06:06:15Z","timestamp":1764828375000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/edm2.70099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":194,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1002\/edm2.70099"],"URL":"https:\/\/doi.org\/10.1002\/edm2.70099","archive":["Portico"],"relation":{},"ISSN":["2398-9238","2398-9238"],"issn-type":[{"value":"2398-9238","type":"print"},{"value":"2398-9238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"2025-05-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70099"}}