{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T10:45:36Z","timestamp":1768905936197,"version":"3.49.0"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:00:00Z","timestamp":1761609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Endocrino Diabet &amp;amp; Metabol"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This systematic review and meta\u2010analysis evaluated the efficacy and safety of the iLet bionic pancreas (iLet BP), a novel automated insulin delivery (AID) system, in managing type 1 diabetes. Unlike conventional AID systems, which require user input for insulin dosing, the iLet BP autonomously determines insulin delivery based solely on body weight. The study synthesized data from five randomized controlled trials (RCTs), comprising a total of 1130 patients, comparing iLet BP with standard care (SC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Outcomes Assessed<\/jats:title>\n                    <jats:p>Primary outcomes included changes in HbA1c, mean glucose levels, and time in target glucose range (70\u2013180\u2009mg\/dL), measured via continuous glucose monitoring (CGM). Secondary outcomes assessed adverse events and hypoglycaemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Findings<\/jats:title>\n                    <jats:p>Results demonstrated that the iLet BP significantly improved glycaemic control. The pooled analysis showed a standardised mean difference (SMD) in HbA1c of \u22120.50 [\u22120.63, \u22120.38] and in mean glucose levels of \u22120.36 [\u22120.50, \u22120.21] favouring iLet BP. Time in target glucose range was significantly higher with iLet BP (SMD: 0.58 [0.43, 0.73]). However, the odds of adverse events were notably higher in the iLet BP group (OR: 15.48 [8.07, 29.70]), while the risk of hypoglycaemia (OR: 2.22 [0.83, 5.94]) was not statistically significant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In conclusion, the iLet BP shows strong potential in improving glycaemic outcomes in patients with type 1 diabetes. However, concerns remain regarding its safety profile, particularly related to adverse events. Further large\u2010scale, high\u2010quality studies are needed to confirm its effectiveness and ensure broader clinical applicability.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/edm2.70127","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T05:04:42Z","timestamp":1761714282000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and Safety of\n                    <scp>iLet<\/scp>\n                    Bionic Pancreas in Patients With Type 1 Diabetes Mellitus: A Systematic Review and Meta Analysis"],"prefix":"10.1002","volume":"8","author":[{"given":"Sunny","family":"Kumar","sequence":"first","affiliation":[{"name":"Wright Center for Graduate Medical Education  Scranton Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. N. U.","family":"Aakash","sequence":"additional","affiliation":[{"name":"Florida State University  Tallahassee Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nisha","family":"Kumari","sequence":"additional","affiliation":[{"name":"Liaquat University of Medical and Health Sciences  Jamshoro Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chandar Kanta","family":"Lohana","sequence":"additional","affiliation":[{"name":"Liaquat University of Medical and Health Sciences  Jamshoro Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alina","family":"Abbas","sequence":"additional","affiliation":[{"name":"King Edward Medical University  Lahore Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. N. U.","family":"Gyaneshwari","sequence":"additional","affiliation":[{"name":"Liaquat University of Medical and Health Sciences  Jamshoro Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raveena","family":"Kumari","sequence":"additional","affiliation":[{"name":"United Medical and Dental College  Karachi Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. N. U.","family":"Eman","sequence":"additional","affiliation":[{"name":"Liaquat University of Medical and Health Sciences  Jamshoro Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reena","family":"Bai","sequence":"additional","affiliation":[{"name":"Liaquat University of Medical and Health Sciences  Jamshoro Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saifullah","family":"Syed","sequence":"additional","affiliation":[{"name":"Royal College of Surgeons  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahveer","family":"Maheshwari","sequence":"additional","affiliation":[{"name":"Liaquat University of Medical and Health Sciences  Jamshoro Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahul","family":"Rai","sequence":"additional","affiliation":[{"name":"Liaquat University of Medical and Health Sciences  Jamshoro Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faiqa","family":"Iqbal","sequence":"additional","affiliation":[{"name":"Shaheed Mohtarma Benazir Bhutto Medical College  Karachi Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Jawwad","sequence":"additional","affiliation":[{"name":"Dow University of Health and Sciences  Karachi Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7498-5937","authenticated-orcid":false,"given":"Hira","family":"Riaz","sequence":"additional","affiliation":[{"name":"Kabul University of Medical Sciences Abu Ali Ibn Sina  Kabul Afghanistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.060244"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.11708"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2021.0514"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2022.0167"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2022.0200"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD008101.pub2"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2022.0341"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102288\u201014\u2010135"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc23-1411"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2022.0201.pub"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S391749"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2004736"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1907863"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2021.0319"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc21-0172"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2023.102847"}],"updated-by":[{"DOI":"10.1002\/edm2.70150","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T00:00:00Z","timestamp":1768694400000}}],"container-title":["Endocrinology, Diabetes &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/edm2.70127","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T22:13:49Z","timestamp":1767824029000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/edm2.70127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,28]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/edm2.70127"],"URL":"https:\/\/doi.org\/10.1002\/edm2.70127","archive":["Portico"],"relation":{},"ISSN":["2398-9238","2398-9238"],"issn-type":[{"value":"2398-9238","type":"print"},{"value":"2398-9238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,28]]},"assertion":[{"value":"2025-07-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70127"}}