{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T09:34:41Z","timestamp":1786872881239,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T00:00:00Z","timestamp":1764460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T00:00:00Z","timestamp":1764460800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Endocrino Diabet &amp;amp; Metabol"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Postoperative hypocalcemia and hypoparathyroidism are common complications after thyroidectomy, often impairing quality of life (QoL). This study investigates the impact of preoperative calcium and magnesium supplementation on postoperative QoL and hypocalcemia in patients undergoing total thyroidectomy for symptomatic nodular goitre or Graves' disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A total of 62 patients undergoing thyroidectomy for benign thyroid diseases were randomised into two groups. The intervention group (IG,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200931) received 500\u2009mg calcium carbonate thrice daily and 300\u2009mg magnesium carbonate once daily for 2\u2009weeks preoperatively, while the control group (CG,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200931) received no supplementation. Laboratory parameters (Ca, Mg, PTH, 25\u2010OH\u2010Vitamin D) were measured at study enrolment (T\n                      <jats:sub>1<\/jats:sub>\n                      ), preoperatively (T\n                      <jats:sub>2<\/jats:sub>\n                      ), immediately postoperatively (T\n                      <jats:sub>3<\/jats:sub>\n                      ) and 6\u2009weeks post\u2010discharge (T\n                      <jats:sub>4<\/jats:sub>\n                      ). QoL was assessed using EQ\u20105D and ThyPro39de questionnaires.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      QoL significantly improved postoperatively in both groups. Patients with Graves' disease in the IG reported earlier QoL improvements immediately post\u2010surgery (T\n                      <jats:sub>3<\/jats:sub>\n                      ). Postoperative hypocalcemia occurred in 19.4% of IG patients and 25% of CG patients, with hypoparathyroidism in 16% and 23%, respectively. The IG demonstrated higher postoperative calcium levels and fewer hypocalcemia symptoms, especially in Graves' disease patients (not significant). Vitamin D deficiency was prevalent (66.7%) but showed no correlation with hypocalcemia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Preoperative calcium and magnesium supplementation might have positive effects on postoperative QoL, especially in Graves' disease patients, and may reduce hypocalcemia symptoms. This simple, inexpensive and low\u2010risk intervention may be beneficial in the preoperative setting prior to thyroidectomy. Although the observed effect did not reach statistical significance, it could still be of clinical relevance. The additional benefit of preoperative magnesium supplementation seems to be of minor significance, while the effect of pre\u2010existing vitamin D deficiency remains uncertain.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/edm2.70129","type":"journal-article","created":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T15:14:41Z","timestamp":1764515681000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of Preoperative Calcium and Magnesium Supplementation on Quality of Life and Hypocalcemia Post\u2010Thyroidectomy"],"prefix":"10.1002","volume":"9","author":[{"given":"Navid","family":"Tabriz","sequence":"first","affiliation":[{"name":"Pius\u2010Hospital Oldenburg, University Hospital for Visceral Surgery Carl von Ossietzky University Oldenburg  Oldenburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Fried","sequence":"additional","affiliation":[{"name":"Pius\u2010Hospital Oldenburg, University Hospital for Visceral Surgery Carl von Ossietzky University Oldenburg  Oldenburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena","family":"Uslar","sequence":"additional","affiliation":[{"name":"Pius\u2010Hospital Oldenburg, University Hospital for Visceral Surgery Carl von Ossietzky University Oldenburg  Oldenburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Weyhe","sequence":"additional","affiliation":[{"name":"Pius\u2010Hospital Oldenburg, University Hospital for Visceral Surgery Carl von Ossietzky University Oldenburg  Oldenburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,30]]},"reference":[{"issue":"1","key":"e_1_2_11_2_1","first-page":"1","article-title":"Indications for the Surgical Management of Benign Goiter in Adults","volume":"115","author":"Bartsch D. 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