{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T22:45:54Z","timestamp":1782859554575,"version":"3.54.5"},"reference-count":78,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Endocrino Diabet &amp;amp; Metabol"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Rhus coriaria\u2009L.<\/jats:italic>\n                      (Anacardiaceae), known as Sumac, is a commonly used spice, which is rich in various classes of phytochemicals including flavonoids, tannins, polyphenolic compounds, organic acids, and may be beneficial for cardiovascular disease risk factors.\u2009This comprehensive systematic review and meta\u2010analysis aimed to assess the impact of Sumac supplementation on cardiovascular disease risk factors, including anthropometric measures, glycemic profile, inflammatory markers, and lipid profile. Additionally, we explored the dose\u2010response relationship and optimal duration of Sumac supplementation for its effects on cardiovascular risk factors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Relevant randomized clinical trials were identified through electronic database searches (PubMed, Scopus, Web of Science, CENTRAL, and EMBASE) up to March 2025. The Cochrane risk\u2010of\u2010bias tool was employed to evaluate study quality. Standardized mean differences (SMDs) in changes between intervention and placebo groups were calculated. A random\u2010effects model, meta\u2010regression, and non\u2010linear modeling explored heterogeneity, dose\u2010response relationships, and the overall impact of Sumac supplementation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fifteen trials, with interventions ranging from 4 to 12\u2009weeks and involving 917 participants, were included. Sumac supplementation demonstrated significant improvements in glycemic and lipid profile. Conversely, no significant effects were observed on other cardiovascular risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Sumac supplementation improved lipid profile, and glycemic parameters suggesting potential benefits in addressing cardiovascular risk factors, despite no significant effects on inflammatory parameters.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/edm2.70135","type":"journal-article","created":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T17:54:28Z","timestamp":1764698068000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Sumac (\n                    <i>Rhus coriaria L.<\/i>\n                    ) and Human Metabolic Health: A Systematic Review and 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