{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:12:50Z","timestamp":1790957570401,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,11,23]],"date-time":"2025-11-23T00:00:00Z","timestamp":1763856000000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Endocrino Diabet &amp;amp; Metabol"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic kidney disease (CKD) affects over half a billion people globally and significantly increases the risk of cardiovascular complications, particularly in those with type 2 diabetes mellitus (T2DM). Although semaglutide, a glucagon\u2010like peptide\u20101 receptor agonist, has shown favourable cardiorenal effects in T2DM patients, prior meta\u2010analyses were limited by small sample sizes and few studies. This updated meta\u2010analysis includes both diabetic and non\u2010diabetic CKD patients, incorporates recently published RCTs and addresses gaps in the literature to enhance result generalizability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>MEDLINE, Embase and Cochrane CENTRAL were searched from inception to May 2025 following PRISMA and AMSTAR guidelines. Studies comparing semaglutide with placebo or standard care in adults (\u2265\u200918\u2009years) with CKD, with or without T2DM were included. Primary outcomes included cardiovascular mortality, major adverse cardiovascular events (MACE), major kidney\u2010related adverse events, nonfatal myocardial infarction and nonfatal stroke. Risk of bias was assessed using Cochrane RoB 2.0.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Five RCTs involving 12,785 participants were included. The findings showed that semaglutide substantially decreased major kidney\u2010related adverse events (defined as a composite outcome encompassing the onset of kidney failure (including long\u2010term dialysis, kidney transplantation or a sustained eGFR reduction to &lt;\u200915\u2009mL\/min\/1.73\u2009m\n                      <jats:sup>2<\/jats:sup>\n                      ), a sustained 50% or greater reduction in eGFR from baseline, or death due to kidney\u2010related causes) (RR: 0.79; 95% CI: 0.71\u20130.87;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.00001;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090%), cardiovascular mortality (RR: 0.74; 95% CI: 0.62\u20130.88;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0008;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200936%) and MACE (defined as a composite of cardiovascular death, nonfatal myocardial infarction and nonfatal stroke) (RR: 0.78; 95% CI: 0.70\u20130.87;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.00001;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Semaglutide demonstrates a favourable safety profile and significant cardiorenal benefits in CKD patients, with or without T2DM. Further research is needed to confirm its effects in non\u2010diabetic CKD populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>International Prospective Register of Systematic Reviews (PROSPERO) registration number: CRD420251019235<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/edm2.70136","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T05:21:24Z","timestamp":1763961684000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Safety and Efficacy of Semaglutide in Patients With Chronic Kidney Disease, With or Without Type 2 Diabetes: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"8","author":[{"given":"Ali","family":"Abdullah","sequence":"first","affiliation":[{"name":"Jinnah Sindh Medical University  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. N. U.","family":"Sagreeka","sequence":"additional","affiliation":[{"name":"Ghulam Muhammad Mahar Medical College  Sukkur Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurdas Alias","family":"Aniket","sequence":"additional","affiliation":[{"name":"Ghulam Muhammad Mahar Medical College  Sukkur Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohan","family":"Lal","sequence":"additional","affiliation":[{"name":"Ghulam Muhammad Mahar Medical College  Sukkur Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. N. 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