{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:34:56Z","timestamp":1791491696665,"version":"4.3.4"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100008036","name":"National Nutrition and Food Technology Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008036","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020481","name":"Shahid Beheshti University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020481","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Endocrino Diabet &amp;amp; Metabol"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hashimoto's thyroiditis (HT) is an inflammatory autoimmune disease and patients with HT may benefit from interventions that incorporate anti\u2010inflammatory components. This study aimed to assess the combined effects of an anti\u2010inflammatory diet and curcumin supplementation on thyroid hormones and lipid profile in patients with HT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This randomised controlled clinical trial was conducted on 57 patients with HT. Patients were randomly assigned to receive either an anti\u2010inflammatory diet plus 1320\u2009mg\/day curcumin or an anti\u2010inflammatory diet plus placebo for 12\u2009weeks. Anthropometric indices, anti\u2010thyroid peroxidase (anti\u2010TPO), thyroid\u2010stimulating hormone (TSH), thyroxine (T4), triiodothyronine (T3), and lipid profile parameters were assessed at baseline and after the 12\u2010week intervention. The trial was registered in the Clinical Trials Database (registration number NCT05975866).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After 12\u2009weeks of intervention, both groups showed reductions in waist circumference and waist\u2010to\u2010hip ratio, with greater changes observed in the curcumin group. However, between\u2010group differences were not statistically significant. A significant reduction in anti\u2010TPO levels was observed in the curcumin group compared to placebo (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006). Although TSH and T3 levels significantly decreased within the curcumin group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.014 and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001, respectively), between\u2010group differences were not statistically significant after adjustment. Additionally, HDL\u2010C levels showed a non\u2010significant trend toward improvement in the curcumin group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.053), whereas other lipid parameters remained unchanged.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Curcumin may have possible benefits for thyroid autoimmunity, but further studies are required before any clinical use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      The trial was registered in the Clinical Trials Database (Registration number: NCT05975866, 08 August 2023). National Nutrition and Food Technology Research Institute NCT0597586\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.clinicaltrials.gov\/study\/NCT05975866?term=NCT05975866&amp;rank=1\">https:\/\/www.clinicaltrials.gov\/study\/NCT05975866?term=NCT05975866&amp;rank=1<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/edm2.70138","type":"journal-article","created":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T17:40:49Z","timestamp":1764697249000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Combined Effects of an Anti\u2010Inflammatory Diet and Curcumin Supplementation on Thyroid Function and Lipid Profile in Patients With Hashimoto's Thyroiditis: A Double Blind Randomised Clinical Trial"],"prefix":"10.1002","volume":"9","author":[{"given":"Fatemeh","family":"Bourbour","sequence":"first","affiliation":[{"name":"Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Behnam","family":"Mahdavi","sequence":"additional","affiliation":[{"name":"Saeed Pathobiology and Genetics Lab  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niayesh","family":"Naghshi","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute Shahid Beheshti University of Medical Sciences  Tehran 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