{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:42:48Z","timestamp":1790689368355,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Endocrino Diabet &amp;amp; Metabol"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Metabolic Dysfunction\u2010Associated Steatotic Liver Disease (MASLD) is a significant health concern and is commonly associated with conditions such as dyslipidemia, insulin resistance, and increased risk of cardiovascular disease. Managing MASLD requires addressing both liver and metabolic dysfunction. Saroglitazar, a dual PPAR\u03b1\/\u03b3 agonist, has shown potential in addressing liver steatosis, fibrosis, and dyslipidemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>This prospective, single\u2010arm, multicentric study with 50 MASLD patients with a mean age of 51.84\u2009\u00b1\u200910.66\u2009years included 33 males. Patients received Saroglitazar magnesium 4\u2009mg in addition to the standard of care for 6\u2009months. The primary objective was to assess changes in liver stiffness measurement (LSM) and controlled attenuation parameter (CAP), and secondary objectives included evaluating changes in metabolic parameters such as fasting blood glucose (FBG), postprandial blood glucose (PPBG), HbA1c, triglyceride levels, and liver enzymes (ALT, alanine aminotransferase; AST, aspartate aminotransferase) at baseline and the end of the study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A statistically significant improvement in hepatic parameters, including LSM and CAP scores, was observed. Concurrently, at the end of the study duration, 16% of patients showed improvement from liver fibrosis stages of F3\/F4 to F0\/F1\/F2 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001), and 76% of patients with severe steatosis (S3) decreased to 38% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). The key metabolic parameters also showed statistically significant reduction in FBG from 140.25\u2009\u00b1\u200951.5\u2009mg\/dL to 117.66\u2009\u00b1\u200918.17\u2009mg\/dL (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004), HbA1c from 7.46%\u2009\u00b1\u20091.44% to 6.83%\u2009\u00b1\u20091.08% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0004) and triglyceride levels from 238.67\u2009\u00b1\u2009168.35\u2009mg\/dL to 167.9\u2009\u00b1\u2009113.89\u2009mg\/dL (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0001). However, during the study, anthropometric parameters remained stable, with a minor increase in BMI (28.91\u2009\u00b1\u20093.5 to 29.12\u2009\u00b1\u20093.67 Kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Despite a slight increase in BMI, Saroglitazar significantly improved transient elastography parameters and hepatic parameters in MASLD patients, suggesting that this drug alone effectively manages MASLD\u2010related metabolic and hepatic dysfunctions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/edm2.70144","type":"journal-article","created":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T08:24:08Z","timestamp":1766737448000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effectiveness of Saroglitazar in\n                    <scp>MASLD<\/scp>\n                    Patients: A Prospective, Real\u2010World Assessment of Liver and Metabolic Health"],"prefix":"10.1002","volume":"9","author":[{"given":"Mukulesh","family":"Gupta","sequence":"first","affiliation":[{"name":"Udyan Health Care Pvt Ltd  Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harshita","family":"Lachhwani","sequence":"additional","affiliation":[{"name":"Harsha Clinic and Diabetes Centre  Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumar Praful","family":"Chandra","sequence":"additional","affiliation":[{"name":"Chandra Diabetes and Heart Clinic  Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajiv","family":"Awasthi","sequence":"additional","affiliation":[{"name":"Prarthana Clinic &amp; Diabetes Care Center  Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7999-2859","authenticated-orcid":false,"given":"Dinesh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Harsha Clinic and Diabetes Centre  Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,26]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(24)00530-5"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.03.039"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.04.008"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.7570\/jomes22021"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29085"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-023-10550-9"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-300342"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.15787"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/flgastro\u20102021\u2010101833"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.14577"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.05.025"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.04.005"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41366-021-00788-4"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-022-00776-2"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2028395"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04912.x"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31843"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.2174\/13894501113149990199"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S49592"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2020.10.051"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201078342\u2010x"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/3920196"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2013.0253"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjpc\/zwae175.380"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000670"},{"issue":"1","key":"e_1_2_12_27_1","first-page":"93","article-title":"Saroglitazar Reduced Liver Fat and Fibrosis in Metabolic Dysfunction Associated Steatotic Liver Disease: A Case Report","volume":"7","author":"Kulkarni R. 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