{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:11:56Z","timestamp":1787508716062,"version":"build-2736575974"},"reference-count":57,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Endocrino Diabet &amp;amp; Metabol"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Hypertension is a major cardiovascular risk factor in individuals with prediabetes and type 2 diabetes (T2D). Curcumin, with its anti\u2010inflammatory and antioxidant properties, has emerged as a potential adjunct therapy, but its effect on blood pressure in this population remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This meta\u2010analysis aimed to evaluate the effects of curcumin or turmeric supplementation on systolic (SBP) and diastolic (DBP) blood pressure in adults with prediabetes or T2D.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic search of PubMed, Scopus, and Web of Science was conducted until August 2025. Randomised controlled trials (RCTs) investigating curcumin\/turmeric supplementation on blood pressure in adults with prediabetes or T2D were included. A meta\u2010analysis was performed using a random\u2010effects model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifteen RCTs comprising 16 treatment arms (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009855 participants) were included. Pooled results indicated that curcumin\/turmeric supplementation significantly reduced SBP (WMD: \u22122.69\u2009mmHg; 95% CI: \u22123.84 to \u22121.55;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200930.1%) compared to control groups. A more substantial reduction in SBP (\u22123.41\u2009mmHg) was observed in the subgroup of participants with baseline hypertension (SBP \u2265\u2009130\u2009mmHg). However, no significant effect was found on DBP (WMD: \u22121.20\u2009mmHg; 95% CI: \u22122.84 to 0.44;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.15;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200984.3%). Subgroup analyses showed significant reductions in SBP in individuals with T2D or prediabetes, in those who were overweight, and with interventions using nano\u2010curcumin, turmeric, or curcumin with piperine at doses &gt;\u20091\u2009g\/day. In addition, subgroup analysis showed that curcumin\/turmeric supplementation led to a significant reduction in DBP in individuals with T2D.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Curcumin\/turmeric supplementation demonstrates a modest, yet significant reduction in SBP in individuals with prediabetes and diabetes, with a more pronounced effect in those with baseline hypertension. Further high\u2010quality RCTs are needed to confirm these findings and establish optimal dosing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/edm2.70145","type":"journal-article","created":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T07:26:15Z","timestamp":1765610775000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Antihypertensive Effects of Curcumin\/Turmeric Supplementation in Prediabetes and Diabetes: A Systematic Review and Meta\u2010Analysis of Randomised Controlled Trials"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3787-2713","authenticated-orcid":false,"given":"Hossein","family":"Bahari","sequence":"first","affiliation":[{"name":"Department of Nutrition, Faculty of Medicine Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Sharifi","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, School of Nutritional Sciences and Food Technology Kermanshah University of Medical Sciences  Kermanshah Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Nejad Shahrokh Abadi","sequence":"additional","affiliation":[{"name":"The Countess of Chester NHS Foundation Trust  Chester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6526-8712","authenticated-orcid":false,"given":"Mostafa","family":"Shahraki Jazinaki","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Faculty of Medicine Mashhad University of Medical Sciences  Mashhad Iran"},{"name":"Student Research Committee Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2648-5109","authenticated-orcid":false,"given":"Haniyeh","family":"Golafrouz","sequence":"additional","affiliation":[{"name":"Rajaei Cardiovascular Medical and Research Center Iran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Asadi","sequence":"additional","affiliation":[{"name":"Student Research Committee Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,12]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119697473.ch3"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/2468-8827.184853"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1163\/26667711-bja10050"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.31703\/gdddr.2024(IX-I).01"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-021-05625-x"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-050219-034524"},{"issue":"10","key":"e_1_2_14_8_1","first-page":"e212","article-title":"2025 AHA\/ACC\/AANP\/AAPA\/ABC\/ACCP\/ACPM\/AGS\/AMA\/ASPC\/NMA\/PCNA\/SGIM Guideline for the Prevention, Detection, Evaluation and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"82","author":"Jones D. 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