{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:25:55Z","timestamp":1792787155942,"version":"4.5.0"},"reference-count":74,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Endocrino Diabet &amp;amp; Metabol"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Tirzepatide, a dual GIP\/GLP\u20101 receptor agonist, offers a novel cardiometabolic strategy beyond glycemic control with important implications for heart failure care. By producing potent, sustained weight reduction and favourable changes in lipids, blood pressure, systemic inflammation and endothelial biology, tirzepatide targets central pathophysiologic drivers of obesity\u2010related HFpEF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted this review to synthesise current evidence on the mechanisms, clinical efficacy and therapeutic implications of tirzepatide for heart failure management, with emphasis on obesity\u2010related HFpEF, cardiorenal effects and safety considerations. Randomised clinical programmes and the SUMMIT outcomes trial have demonstrated symptomatic and functional improvements, reverse cardiac remodelling on imaging, reduced circulating markers of myocardial stress and fewer worsening heart\u2010failure events versus placebo, alongside signals of renal stabilisation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The tolerability profile aligns with the GLP\u20101 class, with gastrointestinal events predominating and a low risk of clinically important hypoglycemia; biliary events may be more likely at higher doses, while pancreatitis risk has not been clearly elevated. Data in HFrEF remain limited and caution is advised given prior mixed results with incretin therapies and theoretical concerns about rapid weight loss in advanced systolic failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This review integrates mechanistic insights and contemporary trial evidence to clarify how dual incretin agonism may modify the trajectory of obesity\u2010driven heart failure, to inform multidisciplinary clinical decision making, and to highlight key unanswered questions and research priorities needed to define tirzepatide's full role in heart failure management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/edm2.70152","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T08:12:22Z","timestamp":1769069542000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Tirzepatide and Cardiovascular Outcomes: A Narrative Review of Mechanisms, Efficacy and Implications for Heart Failure Management"],"prefix":"10.1002","volume":"9","author":[{"given":"Hamza A.","family":"Abdul\u2010Hafez","sequence":"first","affiliation":[{"name":"Department of Medicine An Najah National University  Nablus Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5122-8200","authenticated-orcid":false,"given":"Ameer","family":"Awashra","sequence":"additional","affiliation":[{"name":"Department of Medicine An Najah National University  Nablus Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sosana","family":"Bdir","sequence":"additional","affiliation":[{"name":"Department of Medicine An Najah National University  Nablus Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1323-2682","authenticated-orcid":false,"given":"Sarah","family":"Saife","sequence":"additional","affiliation":[{"name":"Department of Medicine An Najah National University  Nablus Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qasem","family":"Salah","sequence":"additional","affiliation":[{"name":"Department of Medicine An Najah National University  Nablus Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Barbarawi","sequence":"additional","affiliation":[{"name":"Department of Medicine An Najah National University  Nablus Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thabet","family":"Swaileh","sequence":"additional","affiliation":[{"name":"Department of Medicine An Najah National University  Nablus Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2718-8627","authenticated-orcid":false,"given":"Ahmed","family":"Emara","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine Al\u2010Azhar University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3080-2875","authenticated-orcid":false,"given":"Mohamed S.","family":"Elgendy","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Tanta University  Tanta Gharbia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8300-0262","authenticated-orcid":false,"given":"Abdalhakim","family":"Shubietah","sequence":"additional","affiliation":[{"name":"Department of Medicine Advocate Illinois Masonic Medical Center  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,22]]},"reference":[{"key":"e_1_2_17_2_1","doi-asserted-by":"publisher","DOI":"10.15420\/cfr.2023.05"},{"key":"e_1_2_17_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.14857"},{"key":"e_1_2_17_4_1","unstructured":"B.Bozkurt T.Ahmad K.Alexander et\u00a0al. \u201cHF STATS 2024: Heart Failure Epidemiology and Outcomes Statistics an Updated 2024 Report From the Heart Failure Society of America \u201dhttps:\/\/onlinejcf.com\/article\/S1071\u20109164(24)00232\u2010X\/abstract."},{"key":"e_1_2_17_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.2115"},{"issue":"5","key":"e_1_2_17_6_1","first-page":"537","article-title":"Pharmacotherapy of Heart Failure A.D. 2023. 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