{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T11:56:03Z","timestamp":1785326163191,"version":"3.55.0"},"reference-count":63,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Endocrino Diabet &amp;amp; Metabol"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objective<\/jats:title>\n                    <jats:p>Diabetic foot ulcers (DFUs) involve chronic inflammation, impaired angiogenesis, oxidative stress, and disrupted fibroblast\u2013keratinocyte interactions. Circular RNAs (circRNAs), a category of stable non\u2010coding RNAs, have become essential regulators of these processes; nevertheless, their comprehensive functions in DFUs are still inadequately characterised. This scoping review integrated clinical, preclinical, and in silico evidence on circRNAs in DFUs to assess their diagnostic, mechanistic, and therapeutic potential.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Systematic searches of MEDLINE, EMBASE, Web of Science, and Google Scholar were conducted on July 16, 2025, according to the PRISMA\u2010ScR guidelines. Eligible papers included clinical investigations of circRNAs in the tissues of patients with DFUs, preclinical animal models assessing circRNA\u2010based therapies, and computational predictions of circRNA\u2010miRNA\u2010mRNA networks. Information was collected on circRNA expression, molecular targets, clinical associations, and therapeutic effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010two studies (7 clinical, 13 preclinical, 2 in silico) were selected. Clinical studies found\n                      <jats:italic>hsa_circ_PRKDC, hsa_circ_072697, hsa_circ_080968<\/jats:italic>\n                      , and\n                      <jats:italic>hsa_circ_0000907<\/jats:italic>\n                      to be associated with wound severity, tissue perfusion, and keratinocyte proliferation in patients with diabetic foot ulcers. Preclinical studies showed that delivery of\n                      <jats:italic>mmu_circHIPK3, mmu_circMYO9B,<\/jats:italic>\n                      and\n                      <jats:italic>mmu_circ_Astn1<\/jats:italic>\n                      via exosomes or nanoparticles improved angiogenesis, epithelial regeneration, and wound closure. However, the silence of\n                      <jats:italic>mmu_circ_0005654<\/jats:italic>\n                      reduced ferroptosis and inflammation. In silico analyses identified potential regulatory axes, such as\n                      <jats:italic>hsa_circ_0089761\/miR\u2010146a\u20105p\/SMAD4<\/jats:italic>\n                      (\n                      <jats:italic>Mothers against decapentaplegic homologue 4<\/jats:italic>\n                      ) and\n                      <jats:italic>hsa_circ_0049271\/miR\u201024\u20103p\/JUNB<\/jats:italic>\n                      , that were associated with inflammatory\u2010angiogenic pathways in this disease.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CircRNAs hold promise for the diagnosis and treatment of DFUs by modulating angiogenesis, inflammation, oxidative stress, and epithelial repair. Standard network\u2010guided therapies are essential to translate circRNA\u2010based strategies into clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/edm2.70155","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T05:46:33Z","timestamp":1767937593000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Circular\n                    <scp>RNAs<\/scp>\n                    in Diabetic Foot Ulcers: A Scoping Review of Clinical, Preclinical, and In Silico Evidence on Diagnostic and Therapeutic Potentials"],"prefix":"10.1002","volume":"9","author":[{"given":"Amir Reza","family":"Ghafourian","sequence":"first","affiliation":[{"name":"Department of Medical Laboratory Sciences, School of Allied Medical Sciences Tehran University of Medical Sciences  Tehran Iran"},{"name":"Students' Scientific Research Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masoomeh","family":"Hamdi","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Sciences, School of Allied Medical Sciences Tehran University of Medical Sciences  Tehran Iran"},{"name":"Students' Scientific Research Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atefeh","family":"Soltan Mohseni","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Sciences, School of Allied Medical Sciences Tehran University of Medical Sciences  Tehran Iran"},{"name":"Students' Scientific Research Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Davoudi","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Sciences, School of Allied Medical Sciences Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid","family":"Choobineh","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Sciences, School of Allied Medical Sciences Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fariba","family":"Nabatchian","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Sciences, School of Allied Medical Sciences Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8064-118X","authenticated-orcid":false,"given":"Reza","family":"Afrisham","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Sciences, School of Allied Medical Sciences Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,8]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v11.i8.1684"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.10578"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/dci22-0043"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.12701\/jyms.2023.00731"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.JAA.0000464276.44117.b1"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.5772\/intechopen.1003834"},{"issue":"10","key":"e_1_2_14_8_1","first-page":"6409","article-title":"PKC\u03b2 Increases ROS Levels Leading to Vascular Endothelial Injury in Diabetic Foot Ulcers","volume":"12","author":"Liu Z.","year":"2020","journal-title":"American Journal of Translational Research"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v16.i3.100329"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110991"},{"issue":"1","key":"e_1_2_14_11_1","article-title":"Biological Functions of Circular RNAs and Their Roles in Occurrence of Reproduction and Gynecological Diseases","volume":"11","author":"Liu K. 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