{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T20:20:02Z","timestamp":1793823602769,"version":"4.6.1"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Endocrino Diabet &amp;amp; Metabol"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The relationship between the triglycerides\u2010to\u2010high\u2010density lipoprotein cholesterol (TG\/HDL\u2010C) ratio and the risk of developing chronic kidney disease (CKD) remains unclear, as CKD is a major health challenge worldwide. This study aimed to investigate the association between the TG\/HDL\u2010C ratio and the risk of developing CKD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      To find studies that examined the association of TG\/HDL\u2010C ratio (without stratification restrictions for TG\/HDL\u2010C) with CKD or renal disorders, PubMed, Embase, Scopus, Google Scholar, and Web of Science databases, as well as study references, were searched by two independent investigators with no time limit until July 31, 2025 by related MeSH Terms. Heterogeneity among studies was assessed using the Cochran's\n                      <jats:italic>Q<\/jats:italic>\n                      and\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      tests. Meta\u2010regression was employed to manage the heterogeneity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eleven studies involving 376,697 participants were included. The pooled prevalence of CKD was 12% (95% CI: 7\u201316). Subgroup analysis showed a significant positive correlation between increasing TG\/HDL\u2010C ratio and increasing CKD prevalence. The prevalence of CKD in quartiles 1, 2, 3, and 4 was 8%, 10%, 12% and 15%, respectively. A high TG\/HDL\u2010C ratio (q4) versus a low one (q1) was significantly associated with increased risk of CKD (OR: 1.26, 95% CI: 1.13, 1.39,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      : 73.8%,\n                      <jats:italic>p<\/jats:italic>\n                      : 0.001). Subgroup analysis showed that the increased risk of CKD in men and women with high versus low TG\/HDL\u2010C ratio was 27% and 23%, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A high versus low TG\/HDL\u2010C ratio was significantly associated with an increased risk of CKD. This association was stronger in men than in women. Despite its limitations, the TG\/HDL\u2010C ratio can be used as a simple, reliable and accessible biomarker for assessing CKD risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/edm2.70161","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T06:16:53Z","timestamp":1769149013000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Association Between the Triglycerides\u2010to\u2010High\u2010Density Lipoprotein\u2010Cholesterol (\n                    <scp>TG<\/scp>\n                    \/\n                    <scp>HDL<\/scp>\n                    \u2010C) Ratio and Chronic Kidney Disease: A Systematic Review and Meta\u2010Analysis of Observational Studies"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0744-2931","authenticated-orcid":false,"given":"Mansour","family":"Bahardoust","sequence":"first","affiliation":[{"name":"Department of Epidemiology, School of Public Health &amp; Safety Shahid Beheshti University of Medical Sciences  Tehran Iran"},{"name":"Breast Cancer Research Center Iran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1976-0803","authenticated-orcid":false,"given":"Sheida","family":"Shokohyar","sequence":"additional","affiliation":[{"name":"Mass General Hospital Institute of Health Professions  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Delpisheh","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health &amp; Safety Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meisam","family":"Haghmoradi","sequence":"additional","affiliation":[{"name":"Urmia University of Medical Sciences  Urmia Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azin","family":"Ghaffari","sequence":"additional","affiliation":[{"name":"Rajaie Cardiovascular Medical and Research Center Iran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,22]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00519-5"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-024-00820-6"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)32064-5"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfac218"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfz174"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2023.10.018"},{"issue":"1","key":"e_1_2_12_8_1","first-page":"1","article-title":"Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group. 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