{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:30:50Z","timestamp":1791199850405,"version":"4.2.0"},"reference-count":79,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Endocrino Diabet &amp;amp; Metabol"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To compare up\u2010to\u2010date efficacy and safety data of sodium\u2010glucose cotransporter\u20102 inhibitors (SGLT\u20102is) versus other metformin\u2010containing oral dual\u2010therapies (ODTs) in type 2 diabetes mellitus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We updated a 2016 systematic literature review (SLR), searching MEDLINE, Embase, the Cochrane Database of Systematic Reviews, congress abstracts and SLR\/meta\u2010analysis (MA) bibliographies to identify randomised controlled trials. Two independent reviewers determined eligible studies, which were extracted and assessed using the Cochrane Risk of Bias tool. MA was conducted using random\u2010effects pairwise models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We included 36 publications (23 unique studies). Mean differences (MD) indicated comparable change in HbA\n                      <jats:sub>1c<\/jats:sub>\n                      from baseline at Weeks 24 and 52 between SGLT\u20102i plus metformin and other metformin\u2010containing ODTs. Patients on SGLT\u20102i plus metformin showed a significantly lower risk of hypoglycaemia (risk ratio [RR]: 0.27, 95% CI: 0.09, 0.84) and significantly greater weight reduction (MD: \u20132.59; 95% CI: \u22124.42, \u22120.77), but an elevated risk of genital infection (RR: 5.08; 95% CI: 3.49, 7.38) at Week 52 compared with other ODTs. Other safety outcomes (e.g., urinary tract infections) were comparable between SGLT\u20102i plus metformin and other ODTs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Compared with other ODTs, SGLT\u20102i plus metformin exhibited overall comparable efficacy and safety, with a lower risk of hypoglycaemia and greater weight reduction at Week 52.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/edm2.70176","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T11:36:26Z","timestamp":1770896186000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparing\n                    <scp>SGLT2i<\/scp>\n                    and Other Oral Antidiabetic Drugs as Dual Therapy Add\u2010On to Metformin in Type 2 Diabetes: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5931-5846","authenticated-orcid":false,"given":"Yuhang","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism, Shanghai General Hospital Shanghai Jiaotong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Shanghai General Hospital Shanghai Jiaotong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6290-8485","authenticated-orcid":false,"given":"Xiaoying","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Shanghai General Hospital Shanghai Jiaotong University School of Medicine  Shanghai 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