{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T16:56:07Z","timestamp":1781283367746,"version":"3.54.1"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:00:00Z","timestamp":1772668800000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Endocrino Diabet &amp;amp; Metabol"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aims to investigate the changes in cardiometabolic index (CMI) levels in newly diagnosed type 2 diabetes mellitus (T2DM) patients before and after undergoing short\u2010term continuous subcutaneous insulin infusion (CSII) intensive treatment and analyse its correlation with insulin resistance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study retrospectively collected data from 604 patients who were initially diagnosed with T2DM and received short\u2010term CSII treatment during their hospitalisation in the Endocrinology Department of the Affiliated Hospital of Jiangsu University. Clinical data, blood glucose, insulin, C\u2010peptide, blood biochemistry, and other indicators were collected before and after treatment, and CMI was calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Short\u2010term CSII treatment significantly improved blood glucose levels, insulin resistance, and pancreatic \u03b2\u2010cell function in T2DM patients, while downregulating the CMI index (\n                      <jats:italic>p\u2009=<\/jats:italic>\n                      \u20090.002). Correlation analysis showed a positive correlation between CMI and HOMA\u2010IR (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and a negative correlation between CMI and HOMA\u2010\u03b2 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008). Stepwise linear regression model analysis revealed that CMI was independently associated with fasting C\u2010peptide (FCP) before treatment (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20090.291,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001); after treatment, CMI was associated with FCP (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20090.160,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and HOMA\u2010IR (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20090.159,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>After short\u2010term intensive CSII treatment, the CMI level in newly diagnosed T2DM patients significantly decreased, indicating that intensive CSII treatment may have certain significance in improving cardiometabolic function.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/edm2.70192","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T20:24:25Z","timestamp":1773001465000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Short\u2010Term Insulin Pump Therapy on Cardiometabolic Index in Patients With Newly Diagnosed Type 2 Diabetes Mellitus"],"prefix":"10.1002","volume":"9","author":[{"given":"Xia","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Endocrinology Affiliated Hospital of Jiangsu University  Zhenjiang Jiangsu 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