{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T16:55:59Z","timestamp":1781283359071,"version":"3.54.1"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Endocrino Diabet &amp;amp; Metabol"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Thyroglobulin (Tg) is a sensitive and specific marker for differentiated thyroid carcinoma (DTC). The presence of thyroglobulin autoantibodies (TgAb) can interfere with Tg measurement in commonly used immunoassays, often resulting in falsely low or undetectable Tg levels. However, data on the prognostic significance of TgAb or its potential utility as a surrogate marker for DTC are limited, leaving its role in the clinical management of DTC uncertain. The aim of this study was the evaluation of the prognostic significance of TgAb in a clinical cohort of patients with DTC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We included\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009289 patients with DTC who presented to our clinic for radioiodine treatment. Clinical data and follow\u2010up outcomes were retrospectively analysed. The TgAb status at initial treatment and during follow\u2010up was assessed, and its association with disease remission, persistence or recurrence was evaluated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Roughly 25% of DTC patients in our cohort showed positive TgAb post\u2010surgery. There were no significant differences between TgAb\u2010positive and TgAb\u2010negative patients in histology, tumour size, metastasis, therapeutic regimen or risk stratification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The presence of TgAb did not influence the outcome regarding overall and disease\u2010free survival. Results implicate that the initial appearance of TgAb does not influence the outcome of patients with DTC. Patients with positive TgAb should be monitored closely during follow\u2010up as Tg measurement is unreliable, while overtreatment should be avoided.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/edm2.70198","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T01:31:47Z","timestamp":1773279107000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Thyroglobulin Autoantibodies Do Not Influence the Outcome of Patients With Differentiated Thyroid Carcinoma"],"prefix":"10.1002","volume":"9","author":[{"given":"C.","family":"Bornemann","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine University Medical Center G\u00f6ttingen (UMG), Georg\u2010August\u2010University  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0057-5037","authenticated-orcid":false,"given":"C.","family":"Bouter","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine University Medical Center G\u00f6ttingen (UMG), Georg\u2010August\u2010University  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,11]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2016.110"},{"key":"e_1_2_11_3_1","volume-title":"GLOBOCAN 2012 v1. 0, Cancer Incidence and Mortality Worldwide","author":"Ferlay J.","year":"2013"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2014.1"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2015.0020"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.2719"},{"issue":"4","key":"e_1_2_11_7_1","first-page":"1121","article-title":"Serum Thyroglobulin Autoantibodies: Prevalence, Influence on Serum Thyroglobulin Measurement, and Prognostic Significance in Patients With Differentiated Thyroid Carcinoma","volume":"83","author":"Spencer C. A.","year":"1998","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"issue":"3","key":"e_1_2_11_8_1","first-page":"373","article-title":"Thyroid Autoantibodies in Thyroid Cancer: Incidence and Relationship With Tumour Outcome","volume":"119","author":"Pacini F.","year":"1988","journal-title":"Acta Endocrinologica"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-21-0012"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2017-0033"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2018.0195"},{"issue":"3","key":"e_1_2_11_12_1","first-page":"293","article-title":"In Properly Selected Patients With Differentiated Thyroid Cancer, Antithyroglobulin Antibodies Decline After Thyroidectomy and Their Sole Presence Should Not Be an Indication for Radioiodine Ablation","volume":"63","author":"Zavala L. 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