{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T09:03:13Z","timestamp":1785229393823,"version":"3.55.0"},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003970","name":"Isfahan University of Medical Sciences","doi-asserted-by":"publisher","award":["2401257"],"award-info":[{"award-number":["2401257"]}],"id":[{"id":"10.13039\/501100003970","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Endocrino Diabet &amp; Metabol"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Diminished ovarian reserve (DOR) represents a significant contributor to female infertility and adverse reproductive outcomes. Although diet may play a role, the specific impact of phytochemical\u2010rich dietary patterns remains underexplored. So, we aimed to investigate the association between adherence to a dietary phytochemical index (DPI) and the likelihood of DOR among women attending fertility clinics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This case\u2013control study enrolled 370 women, comprising 120 individuals diagnosed with DOR and 250 age\u2010 and body mass index (BMI)\u2010matched controls with normal ovarian reserve. A validated semi\u2010quantitative food frequency questionnaire (FFQ) was applied to assess dietary intakes and, accordingly, DPI was calculated as the proportion of total energy intake obtained from phytochemical\u2010abundant foods. Antral follicle count (AFC) and serum anti\u2010M\u00fcllerian hormone (AMH) measurements were utilized as indicators of ovarian reserve. The association between DPI and the odds of DOR was investigated using multivariable logistic regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Our findings showed that higher DPI was associated with a reduced odds of DOR (Q4 vs. Q1 OR: 0.79; 95% CI: 0.55\u20130.93;\n                      <jats:italic>p<\/jats:italic>\n                      \u2010trend\u2009=\u20090.010). After adjustment for physical activity and energy intake, the association remained significant (OR: 0.80; 95% CI: 0.54\u20130.95;\n                      <jats:italic>p<\/jats:italic>\n                      \u2010trend\u2009=\u20090.033). In the fully adjusted model, which included additional adjustments for fat mass and body mass index, women in the highest DPI quartile had 27% lower odds of DOR compared to those in the lowest quartile (OR: 0.73; 95% CI: 0.42\u20130.97;\n                      <jats:italic>p<\/jats:italic>\n                      \u2010trend\u2009=\u20090.02). Besides, in the control group, AFC differed significantly across DPI quartiles (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), with the highest mean in the second quartile.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings suggest that a phytochemical\u2010rich diet may help reduce the odds of DOR, highlighting the role of diet in reproductive health. However, further prospective studies and mechanistic research are warranted to confirm these results and clarify underlying pathways.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/edm2.70201","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T04:46:07Z","timestamp":1782276367000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dietary Phytochemical Index and Its Relationship With Diminished Ovarian Reserve: Evidence From a Case\u2013Control Study"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0689-6958","authenticated-orcid":false,"given":"Mahdieh","family":"Khodarahmi","sequence":"first","affiliation":[{"name":"Nutrition and Food Security Research Center Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gholamreza","family":"Askari","sequence":"additional","affiliation":[{"name":"Department of Community Nutrition, School of Nutrition and Food Science, Nutrition and Food Security Research Center Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahdi","family":"Vajdi","sequence":"additional","affiliation":[{"name":"Department of Community Nutrition, School of Nutrition and Food Science, Nutrition and Food Security Research Center Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amin","family":"Mokari\u2010Yamchi","sequence":"additional","affiliation":[{"name":"Maternal and Childhood Obesity Research Center Urmia University of Medical Sciences  Urmia Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hatav","family":"Ghasemi\u2010Tehrani","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology School of Medicine, Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Kalatehjari","sequence":"additional","affiliation":[{"name":"Obstetrics &amp; 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