{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T10:04:05Z","timestamp":1779789845535,"version":"3.53.1"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Endocrino Diabet &amp;amp; Metabol"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Long\u2010acting amylin\u2010based therapies (ABTs) are emerging anti\u2010obesity agents; we sought to compare their effects on weight and anthropometric outcomes in adults with overweight\/obesity without diabetes, evaluate gastrointestinal (GI) safety, and rank agents and doses within a network meta\u2010analysis (NMA) framework.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a frequentist random\u2010effects NMA of randomized controlled trials comparing novel ABTs with placebo or active comparators in R. Primary outcome was the percent change in body weight from baseline. Secondary outcomes included absolute weight changes, anthropometric measures, and overall and specific GI adverse events (AEs). Treatments (including dose strata) were compared with placebo within a single network and ranked using P scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Six trials (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u20094642; 12\u201368\u2009weeks) were included. Compared with placebo, high dose (HiD) subcutaneous amycretin produced the largest reduction in percent body weight (mean difference \u221223.95%; P score 1.00), followed by HiD eloralintide (\u221218.01%; P score 0.89) and HiD CagriSema (\u221217.18%; P score 0.85), all exceeding semaglutide 2.4\u2009mg (\u221211.45%) and liraglutide 3.0\u2009mg (\u22126.4%). Almost similar patterns were observed for absolute weight, body mass index, waist circumference and categorical weight\u2010loss thresholds. GI AEs, nausea, vomiting and constipation were more common with HiD ABTs, especially oral amycretin and CagriSema, while diarrhoea mainly increased with semaglutide 2.4\u2009mg. Only HiD CagriSema increased AE\u2010related discontinuation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Novel ABTs, such as HiD amycretin, CagriSema and eloralintide, may induce substantial short\u2010 to medium\u2010term weight loss but may also increase GI AEs; given sparse, low\u2010certainty data, these findings are preliminary and require confirmation in larger trials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      The meta\u2010analysis was registered in PROSPERO (CRD420261340457). The review protocol summary can be accessed at the PROSPERO website (\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.crd.york.ac.uk\/PROSPERO\/view\/CRD420261340457\">https:\/\/www.crd.york.ac.uk\/PROSPERO\/view\/CRD420261340457<\/jats:ext-link>\n                      )\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/edm2.70247","type":"journal-article","created":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T05:51:37Z","timestamp":1779515497000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Novel Amylin\u2010Based Therapies for Weight Management in Adults With Overweight or Obesity Without Diabetes: A Network Meta\u2010Analysis"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5681-6522","authenticated-orcid":false,"given":"A. B. M.","family":"Kamrul\u2010Hasan","sequence":"first","affiliation":[{"name":"Department of Endocrinology Mymensingh Medical College  Mymensingh Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8995-1058","authenticated-orcid":false,"given":"Ibrahim","family":"Khalil","sequence":"additional","affiliation":[{"name":"Department of Medicine Dhaka Medical College and Hospital  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9378-6505","authenticated-orcid":false,"given":"Kunal","family":"Mahajan","sequence":"additional","affiliation":[{"name":"Department of Cardiology Himachal Heart Institute  Mandi Himachal Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4915-8805","authenticated-orcid":false,"given":"Deep","family":"Dutta","sequence":"additional","affiliation":[{"name":"Department of Endocrinology CEDAR Superspeciality Healthcare  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6656-8569","authenticated-orcid":false,"given":"Mainak","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Rabindranath Tagore International Institute of Cardiac Sciences RN Tagore Hospital  Kolkata West Bengal India"},{"name":"Department of Endocrinology Ramakrishna Mission Seva Pratishthan (RKMSP) &amp; Vivekananda Institute of Medical Sciences (VIMS)  Kolkata West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0886-5255","authenticated-orcid":false,"given":"Joseph M.","family":"Pappachan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Lancashire Teaching Hospitals NHS Trust  Preston UK"},{"name":"Faculty of Science Manchester Metropolitan University  Manchester Greater Manchester UK"},{"name":"Department of Endocrinology, Kasturba Medical College, Manipal Manipal Academy of Higher Education  Manipal Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,22]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicines12030019"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2025.103363"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13300\u2010025\u201001733\u20108"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/dddt.s3225"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1M210"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2026.171480"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2025.107563"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(21)01751\u20107"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2502081"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(21)00845\u2010X"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(25)02155\u20105"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(25)01185\u20107"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(25)01176\u20106"},{"key":"e_1_2_12_15_1","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 6.5 (Updated August 2024)","author":"Higgins J. 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