{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T09:03:02Z","timestamp":1785229382631,"version":"3.55.0"},"reference-count":100,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Endocrino Diabet &amp; Metabol"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Insulin resistance (IR) is one of the important pathologic bases of polycystic ovary syndrome (PCOS) and an important factor contributing to infertility. In patients with PCOS, IR acts not only on insulin\u2010sensitive tissues, such as skeletal muscle, adipose tissue, and liver, but also on the ovaries and endometrium. Localised endometrial IR is closely associated with impaired endometrial receptivity, and proper glucose metabolism is a key factor for embryo implantation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This paper describes the signalling pathways of endometrial glucose metabolism and the transcription factors regulated by endometrial glucose metabolism signalling pathways.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The purpose of this paper is to explore the mechanism of endometrial glucose uptake in local IR and find key intersections in this mechanism. For example, Foxo1, as the intersection of the Insulin Receptor Substrate\u2010Phosphatidylinositol3\u2010kinase\u2010Protein Kinase B\u2010Glucose Transporters (IRS\u2010PI3K\u2010Akt\u2010GLUTs) pathway and the Cyclic Adenosine Monophosphate\u2010 Protein Kinase A\u2010 Calcium ion (cAMP\u2010PKA\u2010Ca\n                      <jats:sup>2+<\/jats:sup>\n                      ) pathway, and as an important biomarker for evaluating endometrial receptivity. It is of great significance for studying the improvement of endometrial receptivity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This article summarises the therapeutic approaches targeting insulin resistance and the enhancement of endometrial receptivity based on the above pathways, so as to provide references and suggestions for future therapeutic strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/edm2.70249","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T09:43:10Z","timestamp":1781170990000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Advances in the Study of Endometrial Receptivity and Glucose Metabolism Mechanisms in Insulin Resistance"],"prefix":"10.1002","volume":"9","author":[{"given":"Si\u2010yan","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Gynaecology and Obstetrics The Second Affiliated Hospital of Fujian Medical University  Quanzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao\u2010rong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics The Second Affiliated Hospital of Fujian Medical University  Quanzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2010hong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics The Second Affiliated Hospital of Fujian Medical University  Quanzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6576-7484","authenticated-orcid":false,"given":"Ling\u2010tao","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics The Second Affiliated Hospital of Fujian Medical University  Quanzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3867-9442","authenticated-orcid":false,"given":"Jing","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics The Second Affiliated Hospital of Fujian Medical University  Quanzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8368-6735","authenticated-orcid":false,"given":"Yan\u2010Chuan","family":"Shi","sequence":"additional","affiliation":[{"name":"Group of Neuroendocrinology Garvan Institute of Medical Research  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4239-2028","authenticated-orcid":false,"given":"Shu","family":"Lin","sequence":"additional","affiliation":[{"name":"Group of Neuroendocrinology Garvan Institute of Medical Research  Sydney Australia"},{"name":"Centre of Neurological and Metabolic Research The Second Affiliated Hospital of Fujian Medical University  Quanzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi\u2010rong","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics The Second Affiliated Hospital of Fujian Medical University  Quanzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,11]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24043140"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13048-022-01091-0"},{"key":"e_1_2_14_4_1","doi-asserted-by":"crossref","unstructured":"A. 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